FLT3LG Gene Summary [Human]
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FLT3LG |
| Official Name | fms related receptor tyrosine kinase 3 ligand [Source:HGNC Symbol;Acc:HGNC:3766] |
| Ensembl ID | ENSG00000090554 |
| Bio databases IDs | |
| Aliases | fms related receptor tyrosine kinase 3 ligand |
| Synonyms | FL, FLG3L, FLT3L, FLT3 LIGAND, FMS-like tyrosine kinase 3 ligand, Fms related receptor tyrosine kinase 3 ligand, FMS-RELATED TYROSINE KINASE 3 LIGAND, Gm45713, IMD125, LOC102547607, LOC103691111, Ly72L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FLT3LG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor tyrosine kinase binding
- flt3 ligand
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the FLT3LG gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- epithelial cancer
- neoplasia
- rheumatoid arthritis
- delayed hypersensitive reaction
- androgenic alopecia
- hypoplasia
- cardiac hypertrophy
- vasculitis
role in cell
- expression in
- quantity
- activation in
- apoptosis
- proliferation
- survival
- phosphorylation in
- cell viability
- synthesis in
- priming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FLT3LG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic hemopoiesis
- signal transduction
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- cytosol
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- receptor binding
- receptor tyrosine kinase binding