Muc4 Gene Summary [Mouse]
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface. A large 5' exon encodes at least 15 tandem repeats of 124-126 amino acids. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Muc4 |
| Official Name | mucin 4 [Source:NCBI gene (formerly Entrezgene);Acc:140474] |
| Ensembl ID | ENSMUSG00000118672 |
| Bio databases IDs | |
| Aliases | mucin 4 |
| Synonyms | 4933405I11RIK, ASGP, HSA276359, mucin 4, mucin 4, cell surface associated, Psmc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Muc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nidogen-like
- Family of unknown function (DUF5585)
- binding protein
- cytoplasmic domain
- von Willebrand factor type D domain
- Mucin O-glycosylation domain
- AMOP domain
- Neu/ErbB-2 receptor binding
- von Willebrand factor (vWF) type D domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- head and neck squamous cell carcinoma
- nasopharyngeal cancer
- nasopharyngeal carcinoma
- epithelial cancer
- bicuspid aortic valve
- renal clear cell adenocarcinoma
- renal clear cell cancer
- HER2 negative hormone receptor negative breast cancer
role in cell
- activation in
- expression in
- phosphorylation in
- apoptosis
- migration
- aggregation
- binding in
- invasion
- upregulation in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- extracellular vesicles
- Cytoplasm
- cell surface
- Extracellular Space
- apical cell surfaces
- apical membrane
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Muc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- maintenance of gastrointestinal epithelium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- vesicle
- extracellular matrix
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ErbB-2 class receptor binding
- extracellular matrix constituent, lubricant activity