FLII Gene Summary [Human]
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FLII |
| Official Name | FLII actin remodeling protein [Source:HGNC Symbol;Acc:HGNC:3750] |
| Ensembl ID | ENSG00000177731 |
| Bio databases IDs | |
| Aliases | FLII actin remodeling protein |
| Synonyms | 3632430F08Rik, CMD2J, FLI, Fli1, flightless I actin binding protein, FLII actin remodeling protein, FLII, actin remodeling protein, FLIIH, FLIL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FLII often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- leucine rich domain
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- Gelsolin repeat
- DNA binding domain
- actin binding
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary dilated cardiomyopathy
- dilated cardiomyopathy type 2J
- cardiomyopathy
- serous ovarian adenocarcinoma
- serous ovarian cancer
- infection by HIV-1
role in cell
- expression in
- proliferation
- survival
- activation in
- organization
- shortening
- severing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane/cytoplasmic fraction
- Cytoplasm
- perinuclear region
- podosomes
- actin cytoskeleton
- centrosome
- cytosol
- nucleoplasm
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FLII gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- barbed-end actin filament capping
- actin filament severing
- actin polymerization or depolymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- brush border
- focal adhesion
- cytoplasm
- centriolar satellite
- actin cytoskeleton
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- actin binding