Kcnq3 Gene Summary [Rat]
Enables several functions, including calmodulin binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to ammonium ion; nervous system development; and potassium ion transmembrane transport. Located in several cellular components, including axon initial segment; cell surface; and neuronal cell body. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnq3 |
| Official Name | potassium voltage-gated channel subfamily Q member 3 [Source:RGD Symbol;Acc:69222] |
| Ensembl ID | ENSRNOG00000005206 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily Q member 3 |
| Synonyms | BFNC2, EBN2, KV7.3, potassium voltage-gated channel subfamily Q member 3, potassium voltage-gated channel, subfamily Q, member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnq3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- ubiquitin protein ligase binding
- protein kinase binding
- Ion transport protein
- calmodulin binding
- protein binding
- ion channel
- KCNQ voltage-gated potassium channel
- voltage-gated potassium channel
- Ankyrin-G binding motif of KCNQ2-3
- ion channel binding
- voltage-gated ion channel
- cation channel
Pathways
Biological processes and signaling networks where the Kcnq3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- mental retardation
- major depression
- benign familial neonatal seizures
- benign familial neonatal seizures 2
- hereditary disorder
- schizophrenia
- neurodevelopmental disorder
- benign rolandic epilepsy
- coronary artery disease
role in cell
- apoptosis
- differentiation
- hyperexcitability
- firing in
- hyperpolarization
- plasticity
- response by
- exocytosis by
- action potential
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- axon component
- cell surface
- somatodendritic region
- cellular membrane
- nodes of Ranvier
- nerve ending
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnq3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- synaptic transmission
- response to organic cyclic compound
- endocytosis
- exocytosis
- nerve development
- sensory perception of sound
- protein targeting
- mitochondrial depolarization
- cellular response to calcium ion
- protein import into nucleus
- regulation of synaptic plasticity
- apoptosome assembly
- response to auditory stimulus
- membrane hyperpolarization
- gene expression
- cellular response to xenobiotic stimulus
- neuron remodeling
- neuron apoptotic process
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- initial segment
- voltage-gated potassium channel complex
- mitochondrion
- node of Ranvier
- synapse
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- calmodulin binding
- protein binding