Kcnq2 Gene Summary [Rat]
Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in axon initial segment and plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnq2 |
| Official Name | potassium voltage-gated channel subfamily Q member 2 [Source:RGD Symbol;Acc:621504] |
| Ensembl ID | ENSRNOG00000011624 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily Q member 2 |
| Synonyms | BFNC, DEE7, EBN, EBN1, ENB1, HNSPC, KCNA11, KQT2, KV7.2, Nmf134, potassium voltage-gated channel subfamily Q member 2, potassium voltage-gated channel, subfamily Q, member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnq2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- Ion transport protein
- calmodulin binding
- alpha helix
- calmodulin binding domain
- protein binding
- ion channel
- KCNQ voltage-gated potassium channel
- voltage-gated potassium channel
- Ankyrin-G binding motif of KCNQ2-3
- ankyrin binding
- voltage-gated ion channel
- cation channel
- Unstructured region on Potassium channel subunit alpha KvLQT2
Pathways
Biological processes and signaling networks where the Kcnq2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign familial neonatal seizures 1
- hereditary disorder
- early infantile epileptic encephalopathy type 7
- Ohtahara syndrome
- kainic acid-induced epileptic seizure
- mental retardation
- repetitive behavior
- KCNQ2-related disorder
- Huntington disease
- COVID-19
role in cell
- expression in
- apoptosis
- cell death
- differentiation
- transmembrane potential
- action potential
- transmission
- activity
- response by
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- axon component
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- nodes of Ranvier
- synaptic vesicles
- growth cone
- axon initial segments
- gap junctions
- perikaryon
- dendrites
- axon terminals
- mossy fibers
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnq2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- nervous system development
- synaptic transmission
- regulation of action potential
Cellular Component
Where in the cell the gene product is active
- initial segment
- voltage-gated potassium channel complex
- membrane
- node of Ranvier
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- calmodulin binding
- protein binding
- ankyrin binding