LOC100912008 Gene Summary [Rat]
Predicted to enable COPII receptor activity. Predicted to be involved in several processes, including COPII-coated vesicle cargo loading; Golgi organization; and lipoprotein transport. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and nuclear membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum exit site. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC100912008 |
| Official Name | uncharacterized LOC100912008 [Source:RGD Symbol;Acc:6489329] |
| Ensembl ID | ENSRNOG00000005247 |
| Bio databases IDs | |
| Aliases | uncharacterized LOC100912008 |
| Synonyms | 0610010F23Rik, Ab1-205, CMT4K, LOC100912008, MC4DN1, SHY1, Surf, SURF1 cytochrome c oxidase assembly factor, SURF1, cytochrome c oxidase assembly factor, surfeit gene 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100912008 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- SURF1
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Loc100912008 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nuclear type 1 mitochondrial complex iv deficiency
- Leigh syndrome
- hereditary disorder
- mitochondrial disorder
- fatal infantile cardioencephalomyopathy due to cytochrome C oxidase deficiency 2
- Charcot-Marie-Tooth disease type 4K
- cytochrome c oxidase deficiency
- demyelinating peripheral neuropathy
- autosomal recessive nonsyndromic mental retardation
role in cell
- growth
- function
- size
- respiration
- excitotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100912008 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex IV assembly
- aerobic respiration
- respiratory chain complex IV assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity