Pdpn Gene Summary [Rat]
Predicted to enable chemokine binding activity; protein-folding chaperone binding activity; and signaling receptor binding activity. Involved in several processes, including lung development; positive regulation of platelet activation; and response to hyperoxia. Acts upstream of or within cell adhesion; positive regulation of cell migration; and tube morphogenesis. Located in apical plasma membrane. Biomarker of adult respiratory distress syndrome; bacterial pneumonia; nephrosis; and oligohydramnios. Orthologous to human PDPN (podoplanin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdpn |
| Official Name | podoplanin [Source:RGD Symbol;Acc:61819] |
| Ensembl ID | ENSRNOG00000014961 |
| Bio databases IDs | |
| Aliases | podoplanin |
| Synonyms | AGGRUS, D2-40, E11, GP36, Gp38, GP40, HT1A-1, OTS-8, PA2.26, PODOPLANIN, RANDAM-2, RTI140, RTI40, T1A, T1A-2, T1-alpha, T1-α, TI1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdpn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine binding
- Podoplanin
- protein binding
- receptor binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell skin cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- non-small cell lung cancer
- glioblastoma
- glioblastoma cancer
- sarcomatoid malignant mesothelioma
- mesothelioma formation
- atelectasis
role in cell
- apoptosis
- aggregation
- phosphorylation in
- expression in
- proliferation
- adhesion
- formation in
- formation
- colony formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- tetraspanin-enriched microdomain
- cell junction
- ruffle
- Cytoplasm
- invadopodia
- cell surface
- microvesicles
- cellular membrane
- Nucleus
- Mitochondria
- cytoplasmic aggregates
- cytosol
- membrane ruffles
- plasma membrane extracellular face
- apical membrane
- basolateral membrane
- cell membrane-lagging edges
- cytoplasmic vesicles
- peroxisomes
- membrane rafts
- cellular protrusions
- microvilli
- filopodia
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdpn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- wound healing, spreading of cells
- folic acid transport
- signal transduction
- negative regulation of cell proliferation
- regulation of lamellipodium morphogenesis
- regulation of substrate adhesion-dependent cell spreading
- cell adhesion
- lymph node development
- Rho protein signal transduction
- amino acid transport
- positive regulation of epithelial to mesenchymal transition
- positive regulation of extracellular matrix disassembly
- water transport
- lymphatic endothelial cell fate commitment
- actin-mediated cell contraction
- negative regulation of apoptotic process
- lymphangiogenesis
- cell migration
- platelet activation
- positive regulation of cell migration
- lung development
Cellular Component
Where in the cell the gene product is active
- cell projection
- tetraspanin-enriched microdomain
- plasma membrane
- filopodium membrane
- microvillus membrane
- anchoring junction
- membrane
- mitochondrion
- membrane raft
- ruffle
- filopodium
- cytoplasmic vesicle
- ruffle membrane
- cell junction
- cytosol
- basolateral plasma membrane
- apical plasma membrane
- lamellipodium
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- chemokine binding
- folic acid transporter activity
- protein binding
- water transmembrane transporter activity
- chaperone binding
- water channel activity
- amino acid transmembrane transporter activity
- receptor binding