Col18a1 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in response to hydrostatic pressure and response to xenobiotic stimulus. Located in extracellular space. Used to study hepatocellular carcinoma. Biomarker of gastric ulcer and ulcerative colitis. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL18A1 (collagen type XVIII alpha 1 chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col18a1 |
| Official Name | collagen type XVIII alpha 1 chain [Source:RGD Symbol;Acc:70936] |
| Ensembl ID | ENSRNOG00000001229 |
| Bio databases IDs | |
| Aliases | collagen type XVIII alpha 1 chain |
| Synonyms | COLLAGEN type XVIII, collagen, type XVIII, alpha 1, collagen type XVIII alpha 1 chain, collagen, type XVIII, α 1, collagen type XVIII α 1 chain, collagen XVIII, Endostatin, GLCC, KNO, KNO1, KS, MFP, Procollagen, Type XVIII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col18a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NC1 domain
- LamG
- Fz domain
- heparin binding domain
- protein binding
- identical protein binding
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- Concanavalin A-like lectin/glucanases superfamily
- Collagen trimerization domain
- Endostatin-like
- Collagenase NC10 and Endostatin
- Domain of Unknown Function (DUF959)
- Collagen triple helix repeat (20 copies)
- laminin G domain
Pathways
Biological processes and signaling networks where the Col18a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- burn
- endometriosis
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- metastasis
- edema
- hereditary disorder
role in cell
- expression in
- apoptosis
- phosphorylation in
- growth
- activation in
- survival
- proliferation
- cell death
- accumulation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- endoplasmic reticulum lumen
- rough endoplasmatic reticulum
- microfibrils
- microfilaments
- extracellular matrix
- Golgi vesicles
- exosomes
- basement membrane
- Bowman's membrane
- endothelial basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col18a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hydrostatic pressure
- endothelial cell morphogenesis
- skeletal system development
- notochord development
- angiogenesis
- negative regulation of cell proliferation
- cell adhesion
- response to xenobiotic stimulus
- collagen fibril organization
- visual perception
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- basement membrane
- extracellular space
- extracellular vesicular exosome
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- extracellular matrix structural constituent conferring tensile strength