Bmp10 Gene Summary [Rat]
Predicted to enable receptor ligand activity; receptor serine/threonine kinase binding activity; and telethonin binding activity. Involved in positive regulation of cardiac muscle hypertrophy and sarcomere organization. Predicted to be located in Z disc and cell surface. Predicted to be active in extracellular space. Orthologous to human BMP10 (bone morphogenetic protein 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp10 |
| Official Name | bone morphogenetic protein 10 [Source:RGD Symbol;Acc:1562986] |
| Ensembl ID | ENSRNOG00000009316 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 10 |
| Synonyms | b2b2711Clo, bone morphogenetic protein 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoskeletal protein binding
- TGF_beta_SF
- Transforming growth factor beta like domain
- hormone
- protein binding
- receptor binding
- pro domain
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Bmp10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- organismal death
- disrupted blood brain barrier
- pulmonary hypertensive arterial disease
- hypoplasia
- congenital heart disease
- cardiac hypertrophy
- chronic sinusitis
- hepatocellular carcinoma
role in cell
- apoptosis
- proliferation
- activation in
- expression in
- phosphorylation in
- migration
- production in
- growth
- size
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- positive regulation of cartilage development
- ventricular cardiac muscle tissue morphogenesis
- cell adhesion
- heart trabecula formation
- adult heart development
- activin receptor signaling pathway
- negative regulation of cardiac muscle hypertrophy
- kidney development
- negative regulation of cell growth
- positive regulation of transcription, DNA-dependent
- BMP signaling pathway
- positive regulation of cardiac muscle hypertrophy
- positive regulation of SMAD protein import into nucleus
- negative regulation of endothelial cell migration
- positive regulation of cell proliferation involved in heart morphogenesis
- atrial cardiac muscle tissue morphogenesis
- positive regulation of sarcomere organization
- sarcomere organization
- cardiac muscle cell proliferation
- positive regulation of gene expression
- ventricular cardiac muscle cell development
- regulation of cardiac muscle contraction
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- Z disc
- extracellular space
- cytoplasm
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- hormone activity
- telethonin binding
- receptor serine/threonine kinase binding