Cpb2 Gene Summary [Rat]
Enables carboxypeptidase activity. Involved in several processes, including liver regeneration; negative regulation of hepatocyte proliferation; and regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (carboxypeptidase B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpb2 |
| Official Name | carboxypeptidase B2 [Source:RGD Symbol;Acc:71035] |
| Ensembl ID | ENSRNOG00000010935 |
| Bio databases IDs | |
| Aliases | carboxypeptidase B2 |
| Synonyms | 1110032P04Rik, 4930405E17Rik, C5A-INACTIVATING FACTOR, carboxypeptidase B2, CPR, CPU, LOC102548985, LOC684726, PCPB, Procpr, TAFI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc carboxypeptidase
- carboxypeptidase
- carboxypeptidase U
- Zn_pept domain
- peptidase
- metallocarboxypeptidase
- M14 family of metallocarboxypeptidases and related proteins
- Carboxypeptidase activation peptide
Pathways
Biological processes and signaling networks where the Cpb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motor dysfunction
- bleeding
- coronary disease
- non-small cell lung carcinoma
- non-small cell lung cancer
- thrombolysis
- alveolitis
- neurological signs
- thrombosis
- hepatic necrosis
role in cell
- proliferation
- quantity
- cellular infiltration by
- activation
- adhesion
- colonization by
- recruitment
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- granules
- azurophil granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibrinolysis
- cellular response to glucose stimulus
- negative regulation of plasminogen activation
- protein catabolic process
- proteolysis
- response to xenobiotic stimulus
- blood coagulation
- positive regulation of extracellular matrix constituent secretion
- fibrinolysis
- negative regulation of hepatocyte proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metallocarboxypeptidase activity