Cpn1 Gene Summary [Rat]
Enables carboxypeptidase activity. Involved in bradykinin catabolic process; protein catabolic process; and response to glucocorticoid. Located in extracellular space. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpn1 |
| Official Name | carboxypeptidase N subunit 1 [Source:RGD Symbol;Acc:70931] |
| Ensembl ID | ENSRNOG00000013439 |
| Bio databases IDs | |
| Aliases | carboxypeptidase N subunit 1 |
| Synonyms | 0610011F20RIK, CARBOXYPEPTIDASE N, carboxypeptidase N, polypeptide 1, carboxypeptidase N subunit 1, CPN, LOC100359859, LOC100361985, SCPN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc carboxypeptidase
- carboxypeptidase
- Zn_pept domain
- lysine carboxypeptidase
- peptidase
- metallocarboxypeptidase
- Peptidase_M14NE-CP-C_like
- M14 family of metallocarboxypeptidases and related proteins
- protein binding
- CarboxypepD_reg-like domain
- Carboxypeptidase regulatory-like domain
Pathways
Biological processes and signaling networks where the Cpn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anaphylotoxin inactivator deficiency
- non-insulin-dependent diabetes mellitus
- COVID-19
- nonalcoholic steatohepatitis
- dermatomyositis
- acute inflammation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bradykinin catabolic process
- peptide metabolic process
- protein catabolic process
- response to glucocorticoid stimulus
- protein processing
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metallocarboxypeptidase activity