Synm Gene Summary [Rat]
Predicted to enable intermediate filament binding activity and vinculin binding activity. Predicted to be a structural constituent of cytoskeleton and structural constituent of muscle. Predicted to be involved in fast-twitch skeletal muscle fiber contraction. Located in intermediate filament. Orthologous to human SYNM (synemin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Synm |
| Official Name | synemin [Source:RGD Symbol;Acc:727872] |
| Ensembl ID | ENSRNOG00000014030 |
| Bio databases IDs | |
| Aliases | synemin |
| Synonyms | 4930412K21RIK, AI852401, DMN, E130104F11, KIAA0353, SYN, SYNEMIN, synemin, intermediate filament protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Synm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CHAD
- intermediate filament binding
- Autophagy protein 16 (ATG16)
- Apg6 coiled-coil region
- structural constituent of muscle
- structural constituent of cytoskeleton
- Ezrin/radixin/moesin, alpha-helical domain
- protein binding activity, bridging
- vinculin binding
- protein binding
- Intermediate filament protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myopathy
- HER2 negative hormone receptor negative breast cancer
- centronuclear myopathy
- uterine serous papillary cancer
- familial colorectal cancer
- dermatomyositis
- hyperactive behavior
role in cell
- proliferation
- phosphorylation in
- number
- expression in
- migration
- size
- organization
- survival
- formation
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- cell periphery
- cellular membrane
- Nucleus
- intermediate filaments
- costameres
- dense granule
- sarcolemma
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Synm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intermediate filament cytoskeleton organization
- fast-twitch skeletal muscle fiber contraction
Cellular Component
Where in the cell the gene product is active
- adherens junction
- intermediate filament cytoskeleton
- neurofilament cytoskeleton
- sarcolemma
- costamere
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- vinculin binding
- structural constituent of cytoskeleton
- intermediate filament binding