Cdon Gene Summary [Rat]
Involved in cell adhesion. Acts upstream of or within smoothened signaling pathway. Located in cell surface. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdon |
| Official Name | cell adhesion associated, oncogene regulated [Source:RGD Symbol;Acc:708433] |
| Ensembl ID | ENSRNOG00000011789 |
| Bio databases IDs | |
| Aliases | cell adhesion associated, oncogene regulated |
| Synonyms | Cd0, CDO, CDON1, cell adhesion associated, oncogene regulated, cell adhesion molecule-related/down-regulated by oncogenes, HPE11, Ihog, ORCAM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdon often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- FN3
- immunoglobulin domain
- Immunoglobulin like
- intracellular domain
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- chronic kidney disease
- holoprosencephaly type 11
- cancer
- fibrosis
- hydrocephalus
- colorectal cancer
- Alzheimer disease
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- differentiation
- fusion
- adhesion
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdon gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- embryonic body morphogenesis
- nervous system development
- myoblast fusion
- anterior/posterior pattern specification
- positive regulation of neuroblast proliferation
- smoothened signaling pathway
- positive regulation of neuron differentiation
- cell adhesion
- cerebral cortex development
- positive regulation of MAPK cascade
- positive regulation of transcription from RNA polymerase II promoter
- lens development in camera-type eye
- embryonic retina morphogenesis in camera-type eye
- positive regulation of small GTPase mediated signal transduction
- neuroblast proliferation
- positive regulation of skeletal muscle tissue development
- positive regulation of protein phosphorylation
- satellite cell differentiation
- cell fate specification
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding