Rbp4 Gene Summary [Rat]
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Rbp4 |
| Official Name | retinol binding protein 4 [Source:RGD Symbol;Acc:3546] |
| Ensembl ID | ENSRNOG00000015518 |
| Bio databases IDs | |
| Aliases | retinol binding protein 4 |
| Synonyms | APP-BP, Crbp IV, MCOPCB10, PLASMA RETINOL-binding, PRBP, RBP, RBPA, Rbp w14367, RDCCAS, retinol binding protein 4, retinol binding protein 4, plasma |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- retinol binding
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
Pathways
Biological processes and signaling networks where the Rbp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- FXR/RXR Activation
- IL-12 Signaling and Production in Macrophages
- LXR/RXR Activation
- Osteoarthritis Pathway
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RAR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- colorectal cancer
- hereditary disorder
- epithelial cancer
- liver cancer
- hypoplasia
- follicular adenoma
- adenoma formation
- Ullrich congenital muscular dystrophy
- non-insulin-dependent diabetes mellitus
role in cell
- production in
- expression in
- apoptosis
- proliferation
- phosphorylation in
- surface area
- activation
- abnormal morphology
- signaling in
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rbp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle cell proliferation
- gluconeogenesis
- female genitalia morphogenesis
- vagina development
- urinary bladder development
- uterus development
- retinol metabolic process
- visual perception
- embryonic retina morphogenesis in camera-type eye
- embryonic skeletal system development
- cardiac muscle tissue development
- heart trabecula formation
- embryonic organ morphogenesis
- heart development
- response to retinoic acid
- eye development
- glucose homeostasis
- positive regulation of immunoglobulin production
- retinol transport
- maintenance of gastrointestinal epithelium
- positive regulation of insulin secretion
- lung development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- retinol transporter activity
- retinal binding
- retinol binding