Niban2 Gene Summary [Rat]
Predicted to enable transcription coactivator activity. Predicted to be involved in several processes, including gonadotropin secretion; negative regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in several cellular components, including adherens junction; cytosol; and nucleoplasm. Orthologous to human NIBAN2 (niban apoptosis regulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Niban2 |
| Official Name | niban apoptosis regulator 2 [Source:RGD Symbol;Acc:1307018] |
| Ensembl ID | ENSRNOG00000015845 |
| Bio databases IDs | |
| Aliases | niban apoptosis regulator 2 |
| Synonyms | 9130404D14Rik, bA356B19.6, C9orf88, FAM129B, MEG-3, MINERVA, niban apoptosis regulator 2, OC58, RGD1307018 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Niban2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ETGE motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- rheumatoid arthritis
- Alzheimer disease
- obesity
- head and neck neoplasia
- idiopathic membranous nephropathy
role in cell
- expression in
- apoptosis
- binding in
- proliferation
- activation in
- production in
- invasion
- inactivation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Niban2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- gonadotropin secretion
- negative regulation of cell proliferation
- axon guidance
- positive regulation of skeletal muscle fiber development
- negative regulation of Notch signaling pathway
- hypomethylation of CpG island
- positive regulation of embryonic development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription regulatory region DNA binding
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- cell differentiation
- negative regulation of DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- adherens junction
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- cadherin binding