Ctsc Gene Summary [Rat]
Enables several functions, including chloride ion binding activity; identical protein binding activity; and protein-folding chaperone binding activity. Involved in positive regulation of proteolysis involved in protein catabolic process. Located in lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctsc |
| Official Name | cathepsin C [Source:RGD Symbol;Acc:2445] |
| Ensembl ID | ENSRNOG00000016496 |
| Bio databases IDs | |
| Aliases | cathepsin C |
| Synonyms | CATC, CATHEPSIN C, CPPI, DIPEPTIDYL PEPTIDASE I, DPP1, DPP-I, HMS, JP, JPD, PALS, PDON1, PLS, Preprodipeptidyl Peptidase1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctsc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- serine endopeptidase
- binding protein
- peptidase
- Cathepsin C exclusion domain
- Peptidase_C1
- apoptotic protease activator
- protein binding
- chaperone binding
- identical protein binding
- dipeptidyl-peptidase I
- phosphatase binding
Pathways
Biological processes and signaling networks where the Ctsc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- collagen antibody-induced arthritis
- sepsis
- squamous cell cancer of the oral cavity
- papillon-lefevre disease
- uterine leiomyoma
- leiomyomatosis
- narcolepsy with cataplexy
- kidney disease
- Barrett syndrome
role in cell
- activation in
- morphology
- growth
- synthesis in
- migration
- generation in
- influx
- infiltration by
- function
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- centrosome
- lysosome
- endoplasmic reticulum lumen
- nucleoplasm
- cytotoxic granule
- transport vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctsc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- apoptotic process
- proteolysis
- T cell mediated cytotoxicity
- proteolysis involved in cellular protein catabolic process
- negative regulation of myelination
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
- lysosome
- nucleoplasm
- endoplasmic reticulum lumen
- extracellular space
- centrosome
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- ER to Golgi transport vesicle
- azurophil granule lumen
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- chloride ion binding
- identical protein binding
- protein binding
- apoptotic protease activator activity
- chaperone binding
- cysteine-type endopeptidase activity
- serine-type endopeptidase activity
- cysteine-type peptidase activity
- dipeptidyl-peptidase activity