Hsd11b2 Gene Summary [Rat]
Enables NAD binding activity and steroid binding activity. Involved in several processes, including glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; and response to insulin. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Used to study hypertension. Biomarker of fetal alcohol spectrum disorder; hypertension; myocardial infarction; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd11b2 |
| Official Name | hydroxysteroid 11-beta dehydrogenase 2 [Source:RGD Symbol;Acc:2835] |
| Ensembl ID | ENSRNOG00000017084 |
| Bio databases IDs | |
| Aliases | hydroxysteroid 11-beta dehydrogenase 2 |
| Synonyms | 11 Beta Hsd, 11-Beta Hsd2, 11Beta Hydroxylsteroid Dehydrogenase Type 2, 11HSD2, 11 β Hsd, 11-β HSD2, AME, AME1, Beta-Hydroxysteroid Dehydrogenase type II, HSD11K, HSD2, hydroxysteroid 11-beta dehydrogenase 2, hydroxysteroid 11-β dehydrogenase 2, SDR9C3, β Hsd2, β-Hydroxysteroid Dehydrogenase type II |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hsd11b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD or NADH binding
- 11beta-hydroxysteroid dehydrogenase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- steroid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential hypertension
- breast cancer
- hypertension
- apparent mineralocorticoid excess
- neoplasia
- head and neck cancer
- head and neck neoplasia
- cancer
- hyperplasia
- colon cancer
role in cell
- expression in
- activation in
- production in
- apoptosis
- migration
- proliferation
- growth
- quantity
- excitability
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- insoluble fractions
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- endoplasmic reticulum membrane
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hsd11b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- regulation of blood volume by renal aldosterone
- response to hypoxia
- response to insulin stimulus
- cortisol metabolic process
- response to glucocorticoid stimulus
- female pregnancy
- glucocorticoid metabolic process
- response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- NAD binding
- 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
- steroid binding