Adam8 Gene Summary [Rat]
Predicted to enable several functions, including metal ion binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of defense response; positive regulation of intracellular signal transduction; and positive regulation of leukocyte migration. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and podosome. Predicted to be part of alpha9-beta1 integrin-ADAM8 complex. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam8 |
| Official Name | ADAM metallopeptidase domain 8 [Source:RGD Symbol;Acc:1566394] |
| Ensembl ID | ENSRNOG00000017897 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 8 |
| Synonyms | Adam8 predicted, ADAM metallopeptidase domain 8, a disintegrin and metallopeptidase domain 8, CD156, CD156a, E430039A18Rik, MS2, RGD1566394 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- catalytic domain
- ADAMTS cysteine-rich domain 2
- ectodomain
- metalloprotease domain
- cell adhesion molecule binding
- peptidase
- calcium ion binding
- protein binding
- receptor binding
- metallopeptidase
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- ZnMc
- serine endopeptidase
- ADAM cysteine-rich
- zinc ion binding
- Metallo-peptidase family M12B Reprolysin-like
- integrin binding
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- pro domain
Pathways
Biological processes and signaling networks where the Adam8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- colorectal neoplasm
- rheumatoid arthritis
- renal cancer
- renal cell carcinoma
- colorectal neoplasia
- myocardial infarction
- laser induced choroidal neovascularization
- lung cancer
- astrocytoma
role in cell
- apoptosis
- differentiation
- quantity
- cellular infiltration by
- activity
- fusion
- adhesion
- invasion
- chemotaxis
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- outer membranes
- cellular membrane
- inner membrane
- podosomes
- phagolysosome
- secretory granule membrane
- granules
- tertiary granule membrane
- specific granule membrane
- secretory vesicles
- azurophil granules
- specific granules
- tertiary granules
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell differentiation in thymus
- regulation of cell-cell adhesion
- positive regulation of cell adhesion
- negative regulation of neuron apoptotic process
- positive regulation of acute inflammatory response
- positive regulation of epithelial to mesenchymal transition
- positive regulation of eosinophil migration
- inflammatory response
- positive regulation of fibronectin-dependent thymocyte migration
- lymphocyte chemotaxis
- positive regulation of membrane protein ectodomain proteolysis
- signal release
- angiogenesis
- positive regulation of protein processing
- positive regulation of thymocyte apoptotic process
- cellular response to hypoxia
- positive regulation of protein secretion
- positive regulation of neutrophil extravasation
- cell morphogenesis
- extracellular matrix disassembly
- positive regulation of MAPK cascade
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of cellular extravasation
- leukocyte migration involved in inflammatory response
- positive regulation of innate immune response
- positive regulation of bone resorption
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
- proteolysis
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- phagolysosome
- cytoplasm
- specific granule
- alpha9-beta1 integrin-ADAM8 complex
- tertiary granule
- plasma membrane
- tertiary granule membrane
- podosome
- cell surface
- dense core granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- tumor necrosis factor receptor superfamily binding
- calcium ion binding
- cell adhesion molecule binding
- serine-type endopeptidase activity
- metalloendopeptidase activity
- immunoglobulin receptor binding
- metallopeptidase activity