Adamts12 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of cellular response to growth factor stimulus; protein catabolic process; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts12 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 [Source:RGD Symbol;Acc:1307323] |
| Ensembl ID | ENSRNOG00000018865 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 12, ADAM metallopeptidase with thrombospondin type 1 motif, 12, PRO4389 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- thrombospondin-1 motif
- catalytic domain
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- metalloprotease domain
- peptidase
- protein binding
- ADAM-TS Spacer 1
- ZnMc
- ADAM cysteine-rich
- spacer domain
- Reprolysin (M12B) family zinc metalloprotease
- disintegrin-like domain
- Spondin-like TSP1 domain
- pro domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- organismal death
- hepatocellular carcinoma
- Dupuytren contracture
- osteoarthritis
- Behcet disease
- diabetic nephropathy
- stroke
role in cell
- cell death
- adhesion
- differentiation
- number
- response by
- ossification by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- chondrocyte differentiation
- ossification involved in bone maturation
- cellular response to BMP stimulus
- proteolysis
- extracellular matrix organization
- cellular response to interleukin-1
- regulation of inflammatory response
- cellular response to tumor necrosis factor
- proteoglycan catabolic process
- negative regulation of chondrocyte differentiation
- collagen fibril organization
- proteolysis involved in cellular protein catabolic process
- cell migration
- negative regulation of cellular response to hepatocyte growth factor stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity