Mmp17 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within drinking behavior and kidney development. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP17 (matrix metallopeptidase 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp17 |
| Official Name | matrix metallopeptidase 17 [Source:RGD Symbol;Acc:1311541] |
| Ensembl ID | ENSRNOG00000023643 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 17 |
| Synonyms | LOC102550876, matrix metallopeptidase 17, Matrix metalloproteinase membrane type 4, MMP17 isoform 1, MT4-MMP, MT-MMP 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- Matrixin
- metalloexopeptidase
- catalytic domain
- peptidase
- HX
- Zinc-dependent metalloprotease
- enzyme activator activity
- Putative peptidoglycan binding domain
- ZnMc
- zinc ion binding
- aminopeptidase
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- breast cancer
- spondylarthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- migraines
- Dupuytren contracture
- lung cancer
role in cell
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- drinking behavior
- kidney development
- proteolysis
- extracellular matrix organization
- collagen catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloaminopeptidase activity
- enzyme activator activity
- metalloendopeptidase activity