Cacna2d1 Gene Summary [Rat]
Enables voltage-gated calcium channel activity. Involved in calcium ion transmembrane transport; positive regulation of voltage-gated calcium channel activity; and regulation of membrane repolarization during action potential. Part of L-type voltage-gated calcium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna2d1 |
| Official Name | calcium voltage-gated channel auxiliary subunit alpha2delta 1 [Source:RGD Symbol;Acc:2247] |
| Ensembl ID | ENSRNOG00000033531 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
| Synonyms | CACNA2, CACNL2A, calcium channel, voltage-dependent, alpha2/delta subunit 1, calcium channel, voltage-dependent, alpha2/δ subunit 1, calcium voltage-gated channel auxiliary subunit alpha2delta 1, Ca(v)alpha2delta1, CCHL2A, CCHLA2, DEE110, Dhpr alpha2, DHSCCA, Gabapentin receptor alpha 2 delta-1, Gabapentin receptor α 2 δ-1, LINC01112, lncRNA-N3, N-type CA CHANNEL alpha2/delta subunit, N-type CA CHANNEL alpha2/δ subunit, Thrombospondin receptor alpha 2 delta-1, Thrombospondin receptor α 2 δ-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacna2d1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Neuronal voltage-dependent calcium channel alpha 2acd
- von Willebrand factor (vWF) type A domain
- vWFA
- von Willebrand factor type A domain
- Sensor domains of Histidine Kinase receptors
- protein binding
- VWA N-terminal
- ion channel
Pathways
Biological processes and signaling networks where the Cacna2d1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- beta-thalassemia major
- head and neck cancer
- cancer
- chronic renal failure
- HIV infection
- hyperlipidemia
- non-insulin-dependent diabetes mellitus
- obesity
- hypertension
- infection
role in cell
- proliferation
- number
- migration
- response
- long-term potentiation in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cellular membrane
- sarcoplasmic reticulum
- presynaptic membrane
- postsynaptic membrane
- synapse
- transverse tubules
- secretory granules
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacna2d1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- membrane depolarization involved in regulation of bundle of His cardiac muscle cell action potential
- calcium ion transport
- regulation of heart rate by cardiac conduction
- regulation of ventricular cardiomyocyte membrane repolarization
- regulation of calcium ion transport
- calcium ion transport into cytosol
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- sarcoplasmic reticulum
- voltage-gated calcium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated calcium channel activity involved in regulation of bundle of His cardiac muscle cell action potential
- voltage-gated calcium channel activity involved in regulation of cardiac muscle cell action potential
- metal ion binding
- voltage-gated calcium channel activity