Cacna1i Gene Summary [Rat]
Enables low voltage-gated calcium channel activity. Involved in calcium ion import and calcium ion transport into cytosol. Acts upstream of or within calcium ion transport and regulation of membrane potential. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cacna1i |
| Official Name | calcium voltage-gated channel subunit alpha1 I [Source:RGD Symbol;Acc:68944] |
| Ensembl ID | ENSRNOG00000060407 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel subunit alpha1 I |
| Synonyms | alpha1I, Calcium Channel alpha1i, calcium channel, voltage-dependent, alpha 1I subunit, calcium channel, voltage-dependent, α 1I subunit, calcium voltage-gated channel subunit alpha1 I, Ca(V)3.3, CAV3.3, NEDSIS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacna1i often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Ion transport protein
- low voltage-gated calcium channel
- protein binding
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Cacna1i gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Calcium Signaling
- CCR5 Signaling in Macrophages
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Mitochondrial Dysfunction
- Netrin Signaling
- nNOS Signaling in Skeletal Muscle Cells
- Opioid Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sperm Motility
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- metabolic syndrome X
- obesity
- weight gain
- prostate cancer
- major depression
- juvenile rheumatoid arthritis
- bipolar disorder
- schizophrenia
- migraines
regulates
- Ca2+
role in cell
- transmembrane potential
- action potential
- transport in
- synaptic plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacna1i gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- sleep
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- voltage-gated calcium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- high voltage-gated calcium channel activity
- voltage-gated calcium channel activity