Ttf1 Gene Summary [Rat]
Predicted to enable DNA binding activity and chromatin binding activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to act upstream of or within chromatin remodeling and transcription initiation at RNA polymerase I promoter. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleolus. Orthologous to human TTF1 (transcription termination factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttf1 |
| Official Name | transcription termination factor 1 [Source:RGD Symbol;Acc:1565673] |
| Ensembl ID | ENSRNOG00000039777 |
| Bio databases IDs | |
| Aliases | transcription termination factor 1 |
| Synonyms | AV245725, E130112J05, RGD1565673, transcription termination factor 1, transcription termination factor, RNA polymerase I, TTF-I |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ttf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- Myb-like DNA-binding domain
- chromatin binding
- protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Ttf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- small cell lung cancer
- malignant pleural mesothelioma
- lung adenocarcinoma formation
- lung carcinoma process
- plantar wart
- lung adenocarcinoma
- pleural mesothelioma
- mesothelioma formation
role in cell
- cell death
- apoptosis
- proliferation
- growth
- migration
- remodeling
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ttf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- termination of RNA polymerase I transcription
- negative regulation of DNA replication
- transcription termination, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chromatin binding