Vti1a Gene Summary [Rat]
Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; synaptic vesicle to endosome fusion; and vesicle fusion with Golgi apparatus. Located in several cellular components, including clathrin-coated vesicle; neuronal cell body; and perinuclear region of cytoplasm. Part of SNARE complex. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Orthologous to human VTI1A (vesicle transport through interaction with t-SNAREs 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vti1a |
| Official Name | vesicle transport through interaction with t-SNAREs 1A [Source:RGD Symbol;Acc:621490] |
| Ensembl ID | ENSRNOG00000042786 |
| Bio databases IDs | |
| Aliases | vesicle transport through interaction with t-SNAREs 1A |
| Synonyms | 1110014F16RIK, 1110018K19RIK, 4921537J05RIK, DD6A4-2(1), MMDS3, MVti1, MVti1a, vesicle transport through interaction with t-SNAREs 1A, Vti1, Vti1b, VTI1RP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vti1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- Vesicle transport v-SNARE protein N-terminus
- cytoplasmic domain
- Helical region found in SNAREs
- Snare region anchored in the vesicle membrane C-terminus
- protein binding
- SNARE motif
- 7TM-HD extracellular
Pathways
Biological processes and signaling networks where the Vti1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung carcinoma
- lung carcinoma process
- non-insulin-dependent diabetes mellitus
- colonic polyp
- non-small cell lung carcinoma
- non-small cell lung cancer
- multiple sclerosis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- apoptosis
- growth
- outgrowth
- fusion
- autophagy by
- fusion in
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- perinuclear Golgi regions
- perinuclear membrane
- intracellular space
- perinuclear region
- cellular membrane
- endosomes
- Golgi Apparatus
- cisternae
- Golgi membrane
- trans Golgi network
- synaptic vesicles
- nerve ending
- synapse
- autophagic vacuoles
- early endosomes
- perikaryon
- clathrin-coated vesicles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vti1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- voluntary musculoskeletal movement
- autophagy
- intra-Golgi vesicle-mediated transport
- synaptic vesicle to endosome fusion
- intracellular protein transport
- retrograde transport, endosome to Golgi
- macroautophagy
- endocytic recycling
- vesicle fusion with Golgi apparatus
- Golgi to vacuole transport
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- Golgi membrane
- Golgi apparatus
- neuronal cell body
- neuron projection terminus
- autophagic vacuole
- endoplasmic reticulum membrane
- late endosome membrane
- endosome
- perinuclear region of cytoplasm
- intracellular membrane-bounded organelle
- ER to Golgi transport vesicle membrane
- SNARE complex
- cytosol
- clathrin-coated vesicle
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding