Crybb2 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be a structural constituent of eye lens. Involved in camera-type eye development. Human ortholog(s) of this gene implicated in cataract and cataract 3 multiple types. Orthologous to human CRYBB2 (crystallin beta B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crybb2 |
| Official Name | crystallin, beta B2 [Source:RGD Symbol;Acc:2417] |
| Ensembl ID | ENSRNOG00000050023 |
| Bio databases IDs | |
| Aliases | crystallin, beta B2 |
| Synonyms | beta B2-crystallin, CCA2, CRYB2, CRYB2A, crystallin beta B2, crystallin, beta B2, crystallin β B2, crystallin, β B2, CTRCT3, D22S665, LOC100042920, β B2-crystallin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crybb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- protein binding
- identical protein binding
- Beta/Gamma crystallin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- hereditary disorder
- prostate cancer
- side effect
- COVID-19
- multiple types cataract 3
- osteoporosis
- congenital cataract
- microphthalmia
- cataract disease
regulates
- CRYBA4
- progesterone
- beta-estradiol
role in cell
- apoptosis
- cell cycle progression
- sensitivity
- mitotic index
- solubilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crybb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lens development in camera-type eye
- visual perception
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural molecule activity
- structural constituent of eye lens