Cadm2 Gene Summary [Rat]
This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | Cadm2 |
| Official Name | cell adhesion molecule 2 [Source:RGD Symbol;Acc:1305678] |
| Ensembl ID | ENSRNOG00000030840 |
| Bio databases IDs | |
| Aliases | cell adhesion molecule 2 |
| Synonyms | 2900078E11RIK, 9330131D06, A830029E02Rik, cell adhesion molecule 2, Igdf4d, IGSF4D, NECL3, SynCAM-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cadm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- putative band 4.1 homologues' binding motif
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- bipolar I disorder
- major depression
- sunburn
- dyslexia
- gout
- COVID-19
- benign rolandic epilepsy
- pervasive developmental disorder
role in cell
- accumulation in
- proliferation
- expression in
- migration
- adhesion
- invasion by
- clustering in
- diffusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- postsynaptic membrane
- synapse
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cadm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- neuronal cell body membrane
- synapse
- axon
- plasma membrane