LOC108348190 Gene Summary [Rat]
This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Details
| Type | Retained Intron |
| Official Symbol | LOC108348190 |
| Official Name | uncharacterized LOC108348190 [Source:RGD Symbol;Acc:11520363] |
| Ensembl ID | ENSRNOG00000051964 |
| Bio databases IDs | |
| Aliases | uncharacterized LOC108348190 |
| Synonyms | beta-urogastrone, CN02, EGF-1, epidermal growth factor, epidermal growth factors, epidermal growth factor-urogastrone, HOMG4, LOC103691699, Rac1/Cdc42 activator II, URG, urogastrone, β-urogastrone |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348190 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- membrane-association domain
- ectodomain
- epidermal growth factor receptor binding
- Low-density lipoprotein receptor repeat class B
- protein binding
- EGF-like domain
- growth factor
- EGF_CA
- transmembrane receptor protein tyrosine kinase activator
- guanyl-nucleotide exchange factor
- EGF domain
- receptor agonist activity
- cytosolic tail domain
- loop domain
- Low-density lipoprotein-receptor YWTD domain
- C-terminal extension
- Coagulation Factor Xa inhibitory site
Pathways
Biological processes and signaling networks where the Loc108348190 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign neoplasia
- neoplasia
- epithelial cancer
- neoplastic cell transformation
- ovarian cancer
- ulceration
- weight loss
- hydronephrosis
- schizophrenia
- cleft palate syndrome
role in cell
- cell viability
- expression in
- growth
- degradation in
- cell death
- number
- oxidation in
- differentiation
- killing
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- Golgi Apparatus
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- basolateral membrane
- alpha granules
- late endosomes
- exosomes
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108348190 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- regulation of calcium ion import
- ERBB2-EGFR signaling pathway
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- cerebellar granule cell precursor proliferation
- branching morphogenesis of a tube
- positive regulation of mitosis
- positive regulation of DNA binding
- negative regulation of cholesterol efflux
- negative regulation of secretion
- epithelial cell proliferation
- mammary gland alveolus development
- positive regulation of transcription, DNA-dependent
- angiogenesis
- positive regulation of endothelial cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of phosphorylation
- positive regulation of receptor internalization
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of cerebellar granule cell precursor proliferation
- regulation of JAK-STAT cascade
- positive regulation of MAPK cascade
- positive regulation of hyaluronan biosynthetic process
- ERK1 and ERK2 cascade
- regulation of protein localization at cell surface
- positive regulation of gene expression
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of endothelial cell proliferation
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- extracellular vesicular exosome
- clathrin-coated endocytic vesicle membrane
- extracellular region
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity
- epidermal growth factor receptor binding
- transmembrane receptor protein tyrosine kinase activator activity
- receptor agonist activity