Grb14 Gene Summary [Rat]
Enables phosphoprotein binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Located in endosome. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GRB14 (growth factor receptor bound protein 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grb14 |
| Official Name | growth factor receptor bound protein 14 [Source:RGD Symbol;Acc:61869] |
| Ensembl ID | ENSRNOG00000052498 |
| Bio databases IDs | |
| Aliases | growth factor receptor bound protein 14 |
| Synonyms | Growth Factor Receptor Bound Protein 14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grb14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor tyrosine kinase binding
- PDK-1 binding domain
- Ubl1_cv_Nsp3_N-like
- between pleckstrin homology and SH2 domain
- protein binding activity, bridging
- PH domain
- phosphoprotein binding
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- BPS (Between PH and SH2)
- proline rich domain
Pathways
Biological processes and signaling networks where the Grb14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- impaired glucose tolerance
- hepatic steatosis
- aldosterone producing adrenocortical adenoma
- adenoma formation
- idiopathic scoliosis
role in cell
- proliferation
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- low-density microsomal fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- Nucleus
- endosomes
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grb14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- insulin receptor signaling pathway
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging
- receptor tyrosine kinase binding
- binding, bridging