Mmp8 Gene Summary [Rat]
Enables metal ion binding activity and peptidase activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of neuroinflammatory response; and positive regulation of tumor necrosis factor production. Located in extracellular space. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp8 |
| Official Name | matrix metallopeptidase 8 [Source:RGD Symbol;Acc:631408] |
| Ensembl ID | ENSRNOG00000009907 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 8 |
| Synonyms | CLG1, HNC, matrix metallopeptidase 8, neutrophil collagenase, PMNL-CL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- Matrixin
- neutrophil collagenase
- cytokine binding
- hemopexin domain
- catalytic domain
- peptidase
- HX
- calcium ion binding
- Zinc-dependent metalloprotease
- Putative peptidoglycan binding domain
- metallopeptidase
- ZnMc
- endopeptidase
- serine endopeptidase
- zinc ion binding
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
- RAR Activation
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- sepsis
- cancer
- neoplasia
- pulmonary emphysema
- metastasis
- abdominal aortic aneurysm
- acute lung injury
- diabetes mellitus
- asthma
role in cell
- phosphorylation in
- apoptosis
- migration
- quantity
- expression in
- proliferation
- growth
- cellular infiltration by
- tyrosine phosphorylation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- cell surface
- organelle lumens
- granules
- cell membrane leading edge
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- extracellular matrix disassembly
- proteolysis
- extracellular matrix organization
- endodermal cell differentiation
- collagen catabolic process
- positive regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- specific granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- tumor necrosis factor binding
- serine-type endopeptidase activity
- endopeptidase activity
- peptidase activity
- metalloendopeptidase activity