Adcy10 Gene Summary [Rat]
Enables ATPase binding activity; adenylate cyclase activity; and manganese ion binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of apoptotic process; and positive regulation of metabolic process. Located in several cellular components, including astrocyte end-foot; central region of growth cone; and neuronal cell body. Orthologous to human ADCY10 (adenylate cyclase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy10 |
| Official Name | adenylate cyclase 10 [Source:RGD Symbol;Acc:708450] |
| Ensembl ID | ENSRNOG00000053410 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 10 |
| Synonyms | 4930431D04Rik, 4931412F17, adenylate cyclase 10, HCA2, HEL-S-7a, hsAC, SAC, SACI, Sacy |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcy10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- binding protein
- adenylate cyclase
- catalytic domain
- Class III nucleotidyl cyclases
- enzyme
- protein binding
- manganese ion binding
Pathways
Biological processes and signaling networks where the Adcy10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Hepatic Cholestasis
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- squamous cell cancer
- familial idiopathic hypercalciuria
- epithelial cancer in situ
- intraepithelial squamous cell carcinoma
- pustular psoriasis
- organismal death
- hairpin sperm flagellum
- guttate psoriasis
- verruca vulgaris
role in cell
- expression in
- growth
- apoptosis
- molecular cleavage in
- survival
- motility
- movement
- transendothelial migration
- ossification by
- contraction by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- microtubule cytoskeleton
- cell periphery
- apical compartment
- basal compartment
- perinuclear region
- cellular membrane
- Nucleus
- centriole
- Mitochondria
- cytosol
- primary cilia
- apical membrane
- growth cone
- neurites
- membrane processes
- perikaryon
- axons
- dendrites
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcy10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cAMP biosynthetic process
- spermatid development
- positive regulation of ATP biosynthetic process
- positive regulation of glycogen catabolic process
- regulation of membrane repolarization
- positive regulation of axon extension
- epithelial cilium movement
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- glucose catabolic process
- positive regulation of ossification
- negative regulation of mitochondrial membrane potential
- positive regulation of cardiac muscle cell apoptotic process
- positive regulation of cardiac muscle hypertrophy
- positive regulation of mitochondrial depolarization
- positive regulation of peptidyl-threonine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- neuronal cell body
- extracellular region
- nucleus
- dendrite
- motile cilium
- perinuclear region of cytoplasm
- cytoplasm
- basal part of cell
- mitochondrion
- cytosol
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- bicarbonate binding
- ATP binding
- manganese ion binding
- adenylate cyclase activity
- ATPase binding