Ptch2 Gene Summary [Rat]
Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Predicted to be involved in negative regulation of smoothened signaling pathway and regulation of cell growth. Predicted to act upstream of or within several processes, including epidermal cell fate specification; hair cycle; and positive regulation of epidermal cell differentiation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in basal cell carcinoma and medulloblastoma. Orthologous to human PTCH2 (patched 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptch2 |
| Official Name | patched 2 [Source:RGD Symbol;Acc:1309039] |
| Ensembl ID | ENSRNOG00000057616 |
| Bio databases IDs | |
| Aliases | patched 2 |
| Synonyms | patched 2, PTC2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptch2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The Eukaryotic (Putative) Sterol Transporter (EST) Family
- smoothened binding
- Sterol-sensing domain of SREBP cleavage-activation
- protein binding
- hedgehog receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ptch2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- cancer
- metastasis
- liver neoplasia
- sarcoma
- exhaustion
- angiectasis
- splenomegaly
role in cell
- growth
- expression in
- differentiation
- production in
- mobilization
- loss
- depletion
- cell cycle progression
- signaling in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptch2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of epidermal cell differentiation
- epidermal cell fate specification
- regulation of cell growth
- cell fate determination
- skin development
- negative regulation of smoothened signaling pathway
- hair cycle
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- smoothened binding
- hedgehog family protein binding
- hedgehog receptor activity