Pafah1b2 Gene Summary [Rat]
Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity; identical protein binding activity; and platelet-activating factor acetyltransferase activity. Predicted to be involved in positive regulation of macroautophagy and spermatogenesis. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pafah1b2 |
| Official Name | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 [Source:RGD Symbol;Acc:620332] |
| Ensembl ID | ENSRNOG00000057102 |
| Bio databases IDs | |
| Aliases | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 |
| Synonyms | 2610005M20Rik, alpha 2 PAF-AH subunit, AU021353, HEL-S-303, mus[b], PAF ACETYLHYDROLASE type I, Paf-ah, Pafahb, PAFAH IB2, PAFAH Isoform 1 α 2 subunit, platelet activating factor acetylhydrolase 1b catalytic subunit 2, platelet-activating factor acetylhydrolase 1b, catalytic subunit 2, platelet-activating factor acetylhydrolase, isoform 1b, subunit 2, α 2 PAF-AH subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pafah1b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SGNH_hydrolase
- GDSL-like Lipase/Acylhydrolase family
- 1-alkyl-2-acetylglycerophosphocholine esterase
- binding protein
- protein homodimerization
- enzyme
- protein binding
- identical protein binding
- platelet-activating factor acetyltransferase
- protein heterodimerization
- GDSL-like Lipase/Acylhydrolase
Pathways
Biological processes and signaling networks where the Pafah1b2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- azoospermia
- primary genetic hyperlipidemia
- metabolic syndrome X
role in cell
- apoptosis
- degradation in
- number
- CSN5i-3 sensitivity
- spermatogenesis
- abnormal morphology
- hydrolysis in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Plasma Membrane
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pafah1b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- spermatogenesis
- lipid metabolic process
- lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- 1-alkyl-2-acetylglycerophosphocholine esterase complex
- cytosol
- secretory granule lumen
- nucleolus
- extracellular region
- fibrillar center
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- platelet-activating factor acetyltransferase activity
- protein heterodimerization activity
- 1-alkyl-2-acetylglycerophosphocholine esterase activity