NAT1 Gene Summary [Human]
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Processed Transcript |
| Official Symbol | NAT1 |
| Official Name | N-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:7645] |
| Ensembl ID | ENSG00000171428 |
| Bio databases IDs | |
| Aliases | N-acetyltransferase 1, arylamine N-acetyltransferase 1 |
| Synonyms | AAC1, arylamine N-acetyltransferase-1, MNAT, N-acetyl transferase 1, NATI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NAT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetyltransferase
- N-hydroxyarylamine O-acetyltransferase
- arylamine N-acetyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- colorectal cancer
- major depression
role in cell
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NAT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- arylamine N-acetyltransferase activity