Il17d Gene Summary [Mouse]
Predicted to enable cytokine activity and protein homodimerization activity. Predicted to be involved in inflammatory response; negative regulation of hemopoiesis; and positive regulation of cytokine production. Predicted to be located in extracellular space. Is expressed in central nervous system; ganglia; nucleus pulposus; and thymus primordium. Orthologous to human IL17D (interleukin 17D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il17d |
| Official Name | interleukin 17D [Source:MGI Symbol;Acc:MGI:2446510] |
| Ensembl ID | ENSMUSG00000050222 |
| Bio databases IDs | |
| Aliases | interleukin 17D |
| Synonyms | interleukin 17D, LOC100364699, LOC682369 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il17d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- receptor agonist activity
- Interleukin-17
- cytokine
Pathways
Biological processes and signaling networks where the Il17d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- dextran sodium sulfate-induced colitis
- psoriasis
- dental caries
- restless legs syndrome
role in cell
- expression in
- production in
- phosphorylation in
- bacterial burden
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il17d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interleukin-8 production
- inflammatory response
- positive regulation of granulocyte macrophage colony-stimulating factor production
- signal transduction
- positive regulation of interleukin-6 production
- positive regulation of cytokine production involved in inflammatory response
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- receptor agonist activity
- cytokine activity