IL17D
IL17D Gene Summary
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL17D |
| Official Name | interleukin 17D [Source:HGNC Symbol;Acc:HGNC:5984] |
| Ensembl ID | ENSG00000172458 |
| Bio databases IDs | |
| Aliases | interleukin 17D, interleukin 27 |
| Synonyms | interleukin 17D,LOC100364699,LOC682369 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- receptor agonist activity
- Interleukin-17
- cytokine
Pathways
Biological processes and signaling networks where the IL17D gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- IL17D
- ZRANB1
- Ap1
- ACE2
- CCNH
- CD93
disease
- weight loss
- dextran sodium sulfate-induced colitis
- psoriasis
- dental caries
- restless legs syndrome
regulated by
- TGFB1
- TP63
- ODC1
- peritoneal exudate cells
- IFNG
- RNASEH2B
- RBM38
- OAT
- alitretinoin
- CD4+ T-lymphocytes
regulates
- CXCL8
- AKT
- IL6
- SMAD2/3
- DDX5
- pro-inflammatory cytokine
- Reg3g
- p38 MAPK
- Reg3b
- IL1RL2
role in cell
- expression in
- production in
- phosphorylation in
- bacterial burden
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL17D gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of interleukin-8 production
- inflammatory response
- positive regulation of granulocyte macrophage colony-stimulating factor production
- signal transduction
- positive regulation of interleukin-6 production
- positive regulation of cytokine production involved in inflammatory response
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein homodimerization activity
- receptor agonist activity
- cytokine activity