Ncoa3 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II complex binding activity; and transcription coactivator activity. Involved in cell dedifferentiation; positive regulation of stem cell population maintenance; and regulation of stem cell division. Acts upstream of or within several processes, including labyrinthine layer morphogenesis; mammary gland branching involved in thelarche; and negative regulation of stem cell differentiation. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncoa3 |
| Official Name | nuclear receptor coactivator 3 [Source:MGI Symbol;Acc:MGI:1276535] |
| Ensembl ID | ENSMUSG00000027678 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 3 |
| Synonyms | 2010305B15RIK, ACTR, AIB-1, bHLHe42, CAGH16, CTG26, KAT13B, nuclear receptor coactivator 3, pCIP, p/Cip, RAC3, SRC-1, SRC-3, TNRC14, TNRC16, TRAM-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncoa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- histone acetyltransferase domain
- transcription regulator
- LXXLL motif
- transcription co-activator
- transcription activation domain
- androgen receptor binding
- chromatin binding
- estrogen receptor binding
- Unstructured region on nuclear receptor coactivator protein
- nuclear receptor binding domain
- receptor binding domain
- peroxisome proliferator activated receptor binding
- PAS B-subdomain
- Nuclear receptor coactivator
- Steroid receptor coactivator
- helix-loop-helix domain
- Nuclear receptor coactivator, DUF1518
- Gsk3 phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- AD2 domain
- histone acetyltransferase
- nuclear receptor domain
- AD1 domain
- ligand-dependent nuclear receptor interactor
- Domain of unknown function (DUF4927)
- nuclear export signal
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- enzyme binding
- protein domain specific binding
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- activation domain AD1
- sequence-specific DNA binding
- PAS fold
- phosphorylation site
- p300/cbp binding domain
- binding protein
- PAS domain
- double-stranded DNA binding
- helix loop helix domain
- CBP binding domain
Pathways
Biological processes and signaling networks where the Ncoa3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- gastrointestinal neoplasia
- epithelial neoplasia
- hepatocellular carcinoma
- colorectal neoplasia
- epithelial cancer
- abdominal cancer
- digestive system cancer
- ovarian cancer
phenotypes
- abnormal tooth morphology
- impaired glucose tolerance
- persistence of hyaloid vascular system
- preweaning lethality incomplete penetrance
- abnormal B cell morphology
- abnormal adipose tissue morphology
- abnormal branching of the mammary ductal tree
- abnormal brown fat cell morphology
- abnormal cell differentiation
- abnormal cell physiology
- abnormal defecation
- abnormal eating behavior
- abnormal epididymal fat pad morphology
- abnormal exercise endurance
- abnormal female reproductive system physiology
- abnormal glucose homeostasis
- abnormal hormone level
- abnormal lymphopoiesis
- abnormal mammary gland development
- abnormal skeletal muscle fiber morphology
- abnormal spleen red pulp morphology
- abnormal vagina epithelium morphology
- cachexia
- decreased adiponectin level
- decreased body size
- decreased body temperature
- decreased body weight
- decreased brown adipose tissue amount
- decreased brown fat cell lipid droplet size
- decreased brown fat cell size
- decreased carbon dioxide production
- decreased cell proliferation
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- decreased circulating estradiol level
- decreased circulating free fatty acid level
- decreased circulating glucagon level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating insulin-like growth factor I level
- decreased circulating triglyceride level
- decreased embryo size
- decreased epididymal fat pad weight
- decreased fibroblast cell migration
- decreased interleukin-1 beta secretion
- decreased litter size
- decreased liver weight
- decreased ovulation rate
- decreased oxygen consumption
- decreased splenocyte apoptosis
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased total body fat amount
- decreased white adipose tissue amount
- decreased white fat cell size
- delayed sexual maturation
- delayed vaginal opening
- disproportionate dwarf
- enlarged spleen
- hyperglycemia
- hypoactivity
- impaired adaptive thermogenesis
- impaired exercise endurance
- improved glucose tolerance
- increased B cell derived lymphoma incidence
- increased B cell number
- increased B cell proliferation
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased T cell proliferation
- increased body weight
- increased carbon dioxide production
- increased circulating insulin-like growth factor I level
- increased circulating interleukin-1 beta level
- increased circulating interleukin-6 level
- increased circulating leptin level
- increased circulating tumor necrosis factor level
- increased energy expenditure
- increased fat cell size
- increased incidence of tumors by chemical induction
- increased insulin sensitivity
- increased interleukin-6 secretion
- increased leukocyte cell number
- increased liver glycogen level
- increased liver triglyceride level
- increased lymphocyte cell number
- increased lymphoma incidence
- increased mitochondria size
- increased oxygen consumption
- increased respiratory quotient
- increased spleen germinal center size
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased susceptibility to endotoxin shock
- increased total body fat amount
- increased tumor necrosis factor secretion
- insulin resistance
- lowered ear position
- no abnormal phenotype detected
- oliguria
- postnatal growth retardation
- premature death
- prolonged estrous cycle
- rough coat
- small liver
- thrombocytopenia
role in cell
- apoptosis
- activation in
- quantity
- cell death
- phosphorylation in
- expression in
- binding in
- production in
- growth
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytoplasmic aggregates
- cytosol
- nuclear foci
- nucleoplasm
- stress granule
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncoa3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- cellular response to estradiol stimulus
- chromatin remodeling
- receptor transactivation
- regulation of stem cell division
- cellular response to hormone stimulus
- cell dedifferentiation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- ligand-dependent nuclear receptor binding
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- protein dimerization activity
- RNA polymerase II core binding
- thyroid hormone receptor binding