Apc Gene Summary [Mouse]
Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation; regionalization; and regulation of apoptotic process. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apc |
| Official Name | APC, WNT signaling pathway regulator [Source:MGI Symbol;Acc:MGI:88039] |
| Ensembl ID | ENSMUSG00000005871 |
| Bio databases IDs | |
| Aliases | APC, WNT signaling pathway regulator |
| Synonyms | APC1, Apc7, APC (PROC), APC regulator of WNT signaling pathway, APC, WNT signaling pathway regulator, BTPS2, CC1, DESMD, DP2, DP2.5, DP3, Familial adenomatous polyposis, GS, mAPC, Min, PPP1R46, RATAPC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Adenomatous polyposis coli tumour suppressor protein
- Beta catenin regulatory domain
- Armadillo/beta-catenin-like repeat
- Unstructured region on APC between 1st two creatine-rich regions
- Unstructured region on APC between APC_crr regions 5 and 6
- Unstructured region on APC between 1st and 2nd catenin-bdg motifs
- protein kinase regulator
- enzyme
- identical protein binding
- EB-binding domain
- PIP-like box
- Samp motif
- Armadillo-associated region on APC
- APC repeat
- basic domain
- Cell division protein ZapB
- EB-1 Binding Domain
- armadillo repeat domain
- beta-catenin binding domain
- ubiquitin protein ligase binding
- microtubule binding domain
- Axin binding domain
- protein kinase binding
- nuclear export signal
- protease binding
- beta-catenin binding
- nuclear localization sequence
- Unstructured region on APC between SAMP and APC_crr
- Coiled-coil N-terminus of APC, dimerization domain
- APC basic domain
- protein binding
- Apc 20 amino acid repeat
- microtubule binding
- binding protein
- Adenomatous polyposis coli (APC) repeat
- gamma-catenin binding
- Armadillo/beta-catenin-like repeats
- Unstructured region on APC between APC_crr and SAMP
- Eb1 binding domain
- microtubule plus-end binding
- catenin binding domain
- PDZ binding motif
- NTR domain
- Apc 15-amino acid repeat
Pathways
Biological processes and signaling networks where the Apc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Autoimmune Thyroid Disease Signaling
- Basal Cell Carcinoma Signaling
- Cdc42 Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- FAK Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Ovarian Cancer Signaling
- Polyamine Regulation in Colon Cancer
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Remodeling of Epithelial Adherens Junctions
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- familial colorectal cancer
- adenoma formation
- gastrointestinal neoplasia
- benign neoplasia
- epithelial neoplasia
- prostate cancer
- hepatocellular carcinoma
- attenuated familial adenomatous polyposis type 1
phenotypes
- abnormal anterior visceral endoderm morphology
- abnormal brain development
- abnormal cell physiology
- abnormal crypts of Lieberkuhn morphology
- abnormal developmental patterning
- abnormal digestive system morphology
- abnormal egg cylinder morphology
- abnormal embryo development
- abnormal embryo size
- abnormal embryonic epiblast morphology
- abnormal embryonic tissue morphology
- abnormal endocardial heart tube morphology
- abnormal enterocyte proliferation
- abnormal floor plate morphology
- abnormal foregut morphology
- abnormal head development
- abnormal hindbrain development
- abnormal intestinal goblet cell morphology
- abnormal intestinal mucosa morphology
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal mammary gland development
- abnormal mesendoderm development
- abnormal neural tube morphology
- abnormal nursing
- abnormal ovarian follicle morphology
- abnormal ovarian folliculogenesis
- abnormal pregnancy
- abnormal primitive node morphology
- abnormal tumor morphology
- abnormal vagina epithelium morphology
- absent corpus luteum
- absent forebrain
- absent male preputial gland
- absent mandible
- absent mature ovarian follicles
- absent midbrain
- absent neural folds
- absent nipple
- acrania
- adrenal gland hyperplasia
- altered tumor pathology
- anemia
- aneuploidy
- cardia bifida
- colon polyps
- decreased NK cell number
- decreased T cell number
- decreased body size
- decreased body weight
- decreased embryo size
- decreased hematocrit
- decreased intestinal adenoma incidence
- decreased macrophage cell number
- decreased splenocyte number
- decreased tumor growth/size
- dermal cysts
- embryonic lethality
- embryonic lethality between implantation and placentation
- embryonic lethality between implantation and somite formation incomplete penetrance
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality complete penetrance
- embryonic-extraembryonic boundary constriction
- epidermal cyst
- extended life span
- gastric polyps
- gastrointestinal hemorrhage
- gastrointestinal tract polyps
- hepatic steatosis
- hunched posture
- hyperlipidemia
- incomplete embryo turning
- increased adenoma incidence
- increased apoptosis
- increased cell proliferation
- increased circulating cholesterol level
- increased circulating free fatty acid level
- increased circulating triglyceride level
- increased colon adenoma incidence
- increased desmoid tumor incidence
- increased gastrointestinal tumor incidence
- increased hepatocellular carcinoma incidence
- increased incidence of induced tumors
- increased incidence of tumors by chemical induction
- increased intestinal adenocarcinoma incidence
- increased intestinal adenoma incidence
- increased large intestine adenocarcinoma incidence
- increased liver tumor incidence
- increased mammary adenocarcinoma incidence
- increased mammary gland tumor incidence
- increased metastatic potential
- increased osteoma incidence
- increased osteosarcoma incidence
- increased pilomatricoma incidence
- increased prostaglandin level
- increased skin tumor incidence
- increased small intestine adenocarcinoma incidence
- increased stomach tumor incidence
- increased trichoepithelioma incidence
- increased tumor growth/size
- increased tumor incidence
- intestinal obstruction
- intestine polyps
- lethality throughout fetal growth and development incomplete penetrance
- mammary gland hyperplasia
- melena
- no abnormal phenotype detected
- ovary atrophy
- perinatal lethality complete penetrance
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality complete penetrance
- rectal hemorrhage
- rectal prolapse
- rostral body truncation
- rostral-caudal axis duplication
- split notochord
- uterus atrophy
role in cell
- apoptosis
- dephosphorylation in
- serine phosphorylation in
- activation in
- quantity
- cell death
- phosphorylation in
- expression in
- survival
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- synaptic vesicle membrane
- mother centriole
- glutaminergic synapse
- microtubule cytoskeleton
- pericentriolar matrix
- axon component
- apical extension
- cytoskeleton
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- postsynaptic region
- filamentous network
- cell cortex
- Plasma Membrane
- centrosome
- Golgi Apparatus
- centriole
- Mitochondria
- microtubules
- microtubule bundles
- microtubule tips
- cell-cell contacts
- granules
- microtubule organizing centers
- cytosol
- apical cytoplasm
- cytoplasmic face of plasma membrane
- membrane ruffles
- apical membrane
- plasma membrane projections
- lateral plasma membrane
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear envelope
- growth cone
- neurites
- nerve ending
- apical cortex
- fibrils
- plus end of microtubule
- tight junctions
- apical cell-cell contacts
- lateral cell-cell contacts
- cellular protrusions
- microvilli
- cell membrane leading edge
- kinetochores
- perikaryon
- axons
- dendrites
- cell-cell adherens junctions
- lamellipodia
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- heart valve development
- insulin receptor signaling pathway
- negative regulation of cell proliferation
- nervous system development
- cell adhesion
- endocardial cushion morphogenesis
- cytokinesis after mitosis
- negative regulation of G1/S transition of mitotic cell cycle
- Wnt receptor signaling pathway
- cell fate specification
- cell migration
- regulation of attachment of spindle microtubules to kinetochore
- regulation of microtubule-based process
- macromolecular complex assembly
- positive regulation of pseudopodium assembly
- negative regulation of microtubule depolymerization
- positive regulation of protein catabolic process
- pattern specification process
- response to DNA damage stimulus
- regulation of microtubule-based movement
- negative regulation of cyclin-dependent protein kinase activity
- negative regulation of canonical Wnt receptor signaling pathway
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of apoptotic process
- tight junction assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- Golgi apparatus
- cytoplasmic microtubule
- kinetochore
- plasma membrane
- microtubule
- nucleoplasm
- beta-catenin destruction complex
- nucleus
- centrosome
- tight junction
- adherens junction
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- ruffle membrane
- catenin complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- gamma-catenin binding
- protein kinase binding
- protein binding
- ubiquitin protein ligase binding
- cadherin binding
- microtubule plus-end binding
- dynein complex binding
- beta-catenin binding
- protein kinase regulator activity
- microtubule binding