SSRP1 Gene Summary [Human]
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | SSRP1 |
| Official Name | structure specific recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:11327] |
| Ensembl ID | ENSG00000149136 |
| Bio databases IDs | |
| Aliases | structure specific recognition protein 1, facilitates chromatin remodeling 80 kDa subunit |
| Synonyms | C81323, FACT, FACT80, Hmg1-rs1, Hmgi-rs3, Hmgox, Preiibf, structure specific recognition protein 1, T160 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSRP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- high mobility group (HMG)-box domain superfamily
- chromatin binding
- protein binding
- Pleckstrin homology-like domain
- POB3-like N-terminal PH domain
- DNA binding
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- p63 binding domain
- basic domain
- Structure-specific recognition protein (SSRP1)
- Histone chaperone Rttp106-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pleural mesothelioma
- mesothelioma formation
- ovarian cancer
role in cell
- apoptosis
- activation in
- cell death
- growth
- expression in
- cell viability
- number
- binding
- organization
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- microtubules
- midbody
- nucleoplasm
- nucleoli
- spindle fibers
- astral microtubules
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSRP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- nucleosome disassembly
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- FACT complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- histone binding
- nucleosome binding