Gli2 Gene Summary [Mouse]
Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in gene expression and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and tube morphogenesis. Located in several cellular components, including axoneme; ciliary tip; and nuclear speck. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Orthologous to human GLI2 (GLI family zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gli2 |
| Official Name | GLI-Kruppel family member GLI2 [Source:MGI Symbol;Acc:MGI:95728] |
| Ensembl ID | ENSMUSG00000048402 |
| Bio databases IDs | |
| Aliases | GLI-Kruppel family member GLI2 |
| Synonyms | CJS, GLI family zinc finger 2, GLI-Kruppel family member GLI2, HPE9, PHS2, THP1, THP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gli2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- transcription activation domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- androgen receptor binding domain
- transcription repression domain
- zinc ion binding
- processing determinant domain
- double-stranded DNA binding
- Zinc-finger double domain
- SYGH motif
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Gli2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Crohn disease
- epithelial cancer
- epithelial neoplasia
- cancer
- ulcerative colitis
- edema
- benign neoplasia
- prostatic carcinoma
- prostate cancer
phenotypes
- abnormal basioccipital bone morphology
- abnormal basisphenoid bone morphology
- abnormal cerebellar foliation
- abnormal developmental patterning
- abnormal epiphyseal plate morphology
- abnormal esophageal smooth muscle morphology
- abnormal esophagus development
- abnormal floor plate morphology
- abnormal foregut morphology
- abnormal frontal bone morphology
- abnormal head shape
- abnormal long bone morphology
- abnormal lung development
- abnormal maxillary dental arch morphology
- abnormal maxillary frontal process morphology
- abnormal motor neuron morphology
- abnormal neural tube closure
- abnormal neural tube morphology
- abnormal neuron differentiation
- abnormal neuron specification
- abnormal notochord morphology
- abnormal palatal shelf elevation
- abnormal palatal shelf fusion at midline
- abnormal parietal bone morphology
- abnormal right lung morphology
- abnormal rostral-caudal axis patterning
- abnormal spinal cord interneuron morphology
- abnormal spinal cord morphology
- abnormal spine curvature
- abnormal tracheal cartilage morphology
- abnormal vertebral body morphology
- absent floor plate
- absent intervertebral disk
- absent lower incisors
- absent maxillary shelf
- absent palatine bone horizontal plate
- absent presphenoid bone
- absent right lung accessory lobe
- absent temporomandibular joint disk
- absent tympanic ring
- absent upper incisors
- bowed radius
- bradykinesia
- cleft secondary palate
- decreased body size
- decreased chondrocyte number
- decreased embryo size
- decreased lung weight
- decreased mesenchymal cell proliferation involved in lung development
- delayed bone ossification
- edema
- esophagus hypoplasia
- esophagus stenosis
- exencephaly
- hydrocephaly
- impaired limb coordination
- increased rib number
- increased type II pneumocyte number
- microcephaly
- no abnormal phenotype detected
- perinatal lethality
- perinatal lethality complete penetrance
- persistence of notochord tissue
- polydactyly
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality complete penetrance
- preweaning lethality complete penetrance
- progressive hair loss
- pulmonary hypoplasia
- reduced cerebellar foliation
- short femur
- short fibula
- short humerus
- short limbs
- short maxilla
- short radius
- short sternum
- short tibia
- short ulna
- small cerebellum
- small lung
- small lung saccule
- small mandible
- small mandibular condyloid process
- thick lung-associated mesenchyme
- thin external granule cell layer
- trachea hypoplasia
- trachea stenosis
role in cell
- apoptosis
- quantity
- proliferation
- cell death
- formation
- signaling in
- killing
- activation in
- growth
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile cilia
- ciliary tip
- Cytoplasm
- cilia
- cellular membrane
- basal bodies
- centrosome
- axonemes
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gli2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell differentiation in thymus
- ventral spinal cord development
- smoothened signaling pathway involved in ventral spinal cord interneuron specification
- axon guidance
- odontogenesis of dentin-containing tooth
- positive regulation of DNA replication
- spinal cord dorsal/ventral patterning
- branching morphogenesis of a tube
- positive regulation of transcription from RNA polymerase II promoter
- proximal/distal pattern formation
- cerebellar cortex morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- skeletal system development
- embryonic digestive tract development
- kidney development
- positive regulation of transcription, DNA-dependent
- hindbrain development
- lung development
- floor plate formation
- tube development
- smoothened signaling pathway
- regulation of transcription, DNA-dependent
- pattern specification process
- developmental growth
- spinal cord ventral commissure morphogenesis
- neuron development
- hindgut morphogenesis
- osteoblast development
- regulation of transcription from RNA polymerase II promoter
- pituitary gland development
- ventral midline development
- mammary gland development
- hair follicle morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cilium
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity