NEDD4
NEDD4 Gene Summary
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | NEDD4 |
| Official Name | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] |
| Ensembl ID | ENSG00000069869 |
| Bio databases IDs | |
| Aliases | NEDD4 E3 ubiquitin protein ligase, receptor-potentiating factor 1 |
| Synonyms | E430025J12Rik,EG639396,Gm7265,KIAA0093,NEDD4-1,NEDD4.1,NEDD4A,NEDD4 E3 ubiquitin protein ligase,neural precursor cell expressed, developmentally down-regulated 4,RPF1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding domain
- G-protein-coupled receptor binding
- enzyme
- phosphoprotein amino acid binding
- Domain with 2 conserved Trp (W) residues
- WW
- ion channel binding
- C2 domain
- catalytic domain
- ubiquitin protein ligase activity
- WW class I binding domain
- Domain Homologous to E6-AP Carboxyl Terminus with
- channel inhibitor
- enzyme binding
- protein domain specific binding
- ubiquitin binding
- protein binding
- ionotropic glutamate receptor binding
- potassium channel inhibitor
- WW domain
- sodium channel inhibitor
- acid-D-amino acid ligase
- HECTc
- ubiquitin ligase-like domain
- ubiquitin-protein transferase activity
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the NEDD4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ABCB1
- YWHAG
- UBE2L3
- SMAD5
- Gag
- ABCG4
- GRB10
- YAP1
- SAMSN1
- PDLIM7
disease
- neoplasia
- endometrial cancer
- epithelial cancer
- rheumatoid arthritis
- tuberculosis
- Dupuytren contracture
- bleeding
- hepatocellular carcinoma
- keloid
- open-angle glaucoma
regulated by
- TNF
- ESR1
- isoproterenol
- hydrogen peroxide
- APP
- Ca2+
- RHOA
- p38 MAPK
- insulin
- PRKCD
regulates
- ERK1/2
- PGR
- CDKN1A
- NFkB (complex)
- PPARG
- AKT1
- SOD2
- NR3C1
- SCNN1B
- KDR
role in cell
- expression in
- accumulation in
- phosphorylation in
- binding in
- growth
- apoptosis
- degradation in
- proliferation
- transactivation in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apicolateral membrane
- glutaminergic synapse
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- trans Golgi network
- nucleoplasm
- microvilli
- chromatin
- clathrin-coated vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NEDD4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- non-lytic virus budding
- protein targeting to lysosome
- regulation of dendrite morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- neuromuscular junction development
- receptor catabolic process
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- cellular response to UV
- regulation of ion transmembrane transport
- negative regulation of sodium ion transmembrane transporter activity
- glucocorticoid receptor signaling pathway
- regulation of synapse organization
- neuron projection development
- lysosomal transport
- positive regulation of protein catabolic process
- positive regulation of nucleocytoplasmic transport
- response to DNA damage stimulus
- ubiquitin-dependent protein catabolic process
- regulation of membrane potential
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- innate immune response
- response to calcium ion
- development involved in symbiotic interaction
- progesterone receptor signaling pathway
- regulation of macroautophagy
- protein K63-linked ubiquitination
- negative regulation of sodium ion transport
- receptor internalization
- positive regulation of protein kinase B signaling cascade
- protein ubiquitination
CELLULAR COMPONENT
Where in the cell the gene product is active
- apicolateral plasma membrane
- Golgi apparatus
- chromatin
- plasma membrane
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- ubiquitin ligase complex
- cytoplasm
- cell cortex
- dendritic spine
- cytosol
- macromolecular complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- RNA polymerase binding
- proline-rich region binding
- protein domain specific binding
- protein binding
- ubiquitin binding
- phosphothreonine binding
- phosphoserine binding
- sodium channel inhibitor activity
- beta-2 adrenergic receptor binding
- enzyme binding