CMTM3 Gene Summary [Human]
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CMTM3 |
| Official Name | CKLF like MARVEL transmembrane domain containing 3 [Source:HGNC Symbol;Acc:HGNC:19174] |
| Ensembl ID | ENSG00000140931 |
| Bio databases IDs | |
| Aliases | CKLF like MARVEL transmembrane domain containing 3 |
| Synonyms | 9430096L06Rik, BNAS2, CKLF-like MARVEL transmembrane domain containing 3, CKLFSF3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CMTM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- liver cancer
- epithelial cancer
- organismal death
- sepsis
- liver damage
- chordoma
- bone cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- invasion by
- degradation in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- cellular membrane
- cytosol
- nuclear envelope
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CMTM3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of B cell receptor signaling pathway
- chemotaxis
- signal transduction
- blastocyst hatching
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- extracellular space
- membrane
- cytoplasmic vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity