Tlr2 Gene Summary [Mouse]
Enables several functions, including amyloid-beta binding activity; lipopeptide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including microglia development; negative regulation of cellular component organization; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including positive regulation of defense response; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlr2 |
| Official Name | toll-like receptor 2 [Source:MGI Symbol;Acc:MGI:1346060] |
| Ensembl ID | ENSMUSG00000027995 |
| Bio databases IDs | |
| Aliases | toll-like receptor 2 |
| Synonyms | CD282, Ly105, TIL4, toll-like receptor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- lipid binding
- signaling receptor activity
- diacylated lipoprotein binding
- SEFIR domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- beta-amyloid binding
- protein binding
- receptor binding
- Leucine Rich repeats (2 copies)
- TIR domain
- identical protein binding
- lipopolysaccharide binding
- triacylated lipoprotein binding
- leucine-rich repeat
- binding protein
- cytoplasmic domain
- BB loop
- transmembrane domain
- intracellular domain
- peptidoglycan binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tlr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- MSP-RON Signaling Pathway
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- Osteoarthritis Pathway
- Phagosome Formation
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Toll-like Receptor Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- infection
- tuberculosis
- epithelial cancer
- epithelial neoplasia
- cancer
- motor dysfunction
- chronic lymphocytic leukemia
- mycosis fungoides
- insulin resistance
phenotypes
- abnormal adrenal cortex morphology
- abnormal adrenal gland morphology
- abnormal adrenal gland secretion
- abnormal airway responsiveness
- abnormal astrocyte morphology
- abnormal astrocyte physiology
- abnormal body fat mass
- abnormal cellular extravasation
- abnormal chemokine level
- abnormal circadian behavior
- abnormal circulating LDL cholesterol level
- abnormal circulating cholesterol level
- abnormal circulating corticosterone level
- abnormal circulating glucose level
- abnormal circulating insulin level
- abnormal circulating lipid level
- abnormal circulating pituitary hormone level
- abnormal cytokine secretion
- abnormal dendritic cell physiology
- abnormal endoplasmic reticulum morphology
- abnormal enterocyte morphology
- abnormal glial cell physiology
- abnormal glucose homeostasis
- abnormal heart morphology
- abnormal heart ventricle morphology
- abnormal hepatocyte morphology
- abnormal innate immunity
- abnormal interleukin level
- abnormal interleukin secretion
- abnormal intestinal epithelium morphology
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal leukocyte migration
- abnormal locomotor activation
- abnormal locomotor behavior
- abnormal locomotor circadian rhythm
- abnormal macrophage physiology
- abnormal mitochondrial shape
- abnormal mitochondrion morphology
- abnormal myelination
- abnormal neuron differentiation
- abnormal osteoclast physiology
- abnormal pancreatic beta cell morphology
- abnormal respiratory system physiology
- abnormal tumor necrosis factor level
- abnormal white fat cell size
- altered response to myocardial infarction
- brain ischemia
- cardiac interstitial fibrosis
- colonic necrosis
- decreased angiogenesis
- decreased body weight
- decreased cerebral infarction size
- decreased circulating VLDL cholesterol level
- decreased circulating alanine transaminase level
- decreased circulating corticosterone level
- decreased circulating insulin level
- decreased circulating interleukin-1 beta level
- decreased circulating leptin level
- decreased circulating tumor necrosis factor level
- decreased fat cell size
- decreased gonadal fat pad weight
- decreased heart left ventricle weight
- decreased heart weight
- decreased immunoglobulin level
- decreased inflammatory response
- decreased interleukin-1 beta secretion
- decreased interleukin-1 secretion
- decreased interleukin-10 secretion
- decreased interleukin-12 secretion
- decreased interleukin-12b secretion
- decreased interleukin-6 secretion
- decreased liver tumor incidence
- decreased lung tumor incidence
- decreased lung weight
- decreased macrophage cytokine production
- decreased macrophage nitric oxide production
- decreased microglial cell activation
- decreased mitochondria number
- decreased neuron apoptosis
- decreased splenocyte proliferation
- decreased susceptibility to Herpesvirales infection
- decreased susceptibility to Herpesvirales infection induced morbidity/mortality
- decreased susceptibility to bacterial infection induced morbidity/mortality
- decreased susceptibility to hepatic steatosis
- decreased susceptibility to kidney reperfusion injury
- decreased susceptibility to parasitic infection
- decreased thermal nociceptive threshold
- decreased tumor necrosis factor secretion
- enlarged adrenal glands
- hepatic steatosis
- hyperresponsive to tactile stimuli
- improved glucose tolerance
- increased B cell apoptosis
- increased T cell number
- increased adipocyte glucose uptake
- increased carcinoma incidence
- increased circulating adrenocorticotropin level
- increased circulating free fatty acid level
- increased colon adenoma incidence
- increased energy expenditure
- increased food intake
- increased gastrointestinal tumor incidence
- increased insulin secretion
- increased insulin sensitivity
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to bacterial infection
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased susceptibility to induced colitis
- insulitis
- no abnormal phenotype detected
- premature death
- rectal hemorrhage
- small pancreatic islets
- weight loss
role in cell
- apoptosis
- binding
- aggregation
- invasion
- phosphorylation in
- expression in
- proliferation
- accumulation in
- growth
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- intracellular compartment
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- cellular membrane
- Golgi Apparatus
- secretory granule membrane
- cytosol
- apical cell surfaces
- plasma membrane extracellular face
- basolateral membrane
- nucleoplasm
- perinuclear space
- membrane rafts
- cellular protrusions
- perikaryon
- exosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- I-kappaB phosphorylation
- response to progesterone stimulus
- detection of triacyl bacterial lipopeptide
- detection of diacyl bacterial lipopeptide
- learning
- response to toxin
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of oligodendrocyte differentiation
- inflammatory response
- immune response
- response to hypoxia
- positive regulation of interferon-beta production
- apoptotic process
- central nervous system myelin formation
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- defense response to Gram-positive bacterium
- negative regulation of synapse assembly
- cellular response to triacyl bacterial lipopeptide
- leukotriene metabolic process
- positive regulation of inflammatory response
- positive regulation of interleukin-8 production
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of gene expression
- lipopolysaccharide-mediated signaling pathway
- positive regulation of Wnt receptor signaling pathway
- positive regulation of interleukin-6 production
- cellular response to diacyl bacterial lipopeptide
- negative regulation of phagocytosis
- toll-like receptor 2 signaling pathway
- negative regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- response to insulin stimulus
- positive regulation of interleukin-18 production
- response to fatty acid
- toll-like receptor TLR6:TLR2 signaling pathway
- signal transduction
- nitric oxide metabolic process
- toll-like receptor signaling pathway
- microglial cell activation
- positive regulation of interleukin-12 production
- cellular response to lipoteichoic acid
- innate immune response
- cellular response to bacterial lipopeptide
- cellular response to interferon-gamma
- positive regulation of interleukin-10 production
- microglia development
Cellular Component
Where in the cell the gene product is active
- Toll-like receptor 1-Toll-like receptor 2 protein complex
- Toll-like receptor 2-Toll-like receptor 6 protein complex
- Golgi apparatus
- receptor complex
- cell projection
- plasma membrane
- cell surface
- secretory granule membrane
- cytoplasm
- cell body
- membrane raft
- phagocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- peptidoglycan binding
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- lipopolysaccharide receptor activity
- signaling receptor activity
- triacyl lipopeptide binding
- Toll-like receptor binding
- beta-amyloid binding
- lipopolysaccharide binding