PKN1 Gene Summary [Human]
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PKN1 |
| Official Name | protein kinase N1 [Source:HGNC Symbol;Acc:HGNC:9405] |
| Ensembl ID | ENSG00000123143 |
| Bio databases IDs | |
| Aliases | protein kinase N1 |
| Synonyms | DBK, F730027O18Rik, PAK-1, PKN, PKN-ALPHA, PKN-α, PRK1, PRKCL1, protein kinase N1, Stk3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PKN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein serine/threonine kinase
- protein kinase
- transcription co-activator
- RhoA binding domain
- regulatory domain
- ATP-binding domain
- androgen receptor binding
- leucine zipper domain
- chromatin binding
- enzyme
- Protein kinase domain
- activation loop
- Extension to Ser/Thr-type protein kinases
- alcohol group acceptor phosphotransferase
- protein kinase C
- Tyrosine kinase, catalytic domain
- Hr1 repeat
- C2 domain
- HR1
- histone binding
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein kinase C binding
- enzyme binding
- histone deacetylase binding
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Rho-binding domain
Pathways
Biological processes and signaling networks where the PKN1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- hyperplasia
- androgenic alopecia
- urolithiasis
- glomerulonephritis
- ureterolithiasis
- glioma
- glioma formation
- chronic fatigue syndrome
- pancreatic carcinoma
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- activation in
- migration
- cell viability
- growth
- invasion by
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal compartment
- ribosome
- Nucleus
- endosomes
- vesicles
- centrosome
- Endoplasmic Reticulum
- microtubules
- midbody
- cytosol
- nucleoplasm
- nuclear envelope
- spine apparatus
- synaptic vesicles
- cytoplasmic vesicles
- multivesicular bodies
- cleavage furrow
- axons
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PKN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- spleen development
- protein phosphorylation
- post-translational protein modification
- hyperosmotic response
- renal system process
- B cell homeostasis
- regulation of androgen receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
- B cell apoptotic process
- chromatin remodeling
- regulation of germinal center formation
- negative regulation of B cell proliferation
- positive regulation of transcription, DNA-dependent
- negative regulation of protein phosphorylation
- regulation of immunoglobulin production
- regulation of cell motility
- peptidyl-serine phosphorylation
- epithelial cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- cytoplasm
- cleavage furrow
- cytosol
- macromolecular complex
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- histone deacetylase binding
- protein kinase activity
- chromatin binding
- protein serine/threonine kinase activity
- protein kinase C activity
- ATP binding
- protein binding
- androgen receptor binding
- histone binding
- ligand-dependent nuclear receptor transcription coactivator activity
- small GTPase binding
- histone kinase activity (H3-T11 specific)