Relb Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of DNA-templated transcription; and non-canonical NF-kappaB signal transduction. Acts upstream of or within T-helper 1 cell differentiation; antigen processing and presentation; and myeloid dendritic cell differentiation. Located in cytosol and nucleus. Is active in synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Relb |
| Official Name | avian reticuloendotheliosis viral (v-rel) oncogene related B [Source:MGI Symbol;Acc:MGI:103289] |
| Ensembl ID | ENSMUSG00000002983 |
| Bio databases IDs | |
| Aliases | avian reticuloendotheliosis viral (v-rel) oncogene related B |
| Synonyms | avian reticuloendotheliosis viral (v-rel) oncogene related B, IMD53, I-REL, RELB proto-oncogene, NF-kB subunit, shep |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Relb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RelB transactivation domain
- transcription regulator
- protein kinase binding
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- RelB leucine zipper
- N-terminal sub-domain of the Rel homology domain (RHD)
- transcription factor activity
Pathways
Biological processes and signaling networks where the Relb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- Adrenomedullin signaling pathway
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Androgen Signaling
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- Apelin Endothelial Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Apoptosis Signaling
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- Atherosclerosis Signaling
- B Cell Activating Factor Signaling
- B Cell Receptor Signaling
- BMP signaling pathway
- CD27 Signaling in Lymphocytes
- CD28 Signaling in T Helper Cells
- LXR/RXR Activation
- NF-κB Signaling
- PEDF Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- neoplasia
- alopecia
- androgenic alopecia
- sepsis
- delayed hypersensitive reaction
- dermatitis
- Alzheimer disease
- hyperkeratosis
phenotypes
- abnormal Peyer's patch morphology
- abnormal antigen presentation
- abnormal bile duct morphology
- abnormal cell-mediated immunity
- abnormal circulating protein level
- abnormal cytokine level
- abnormal cytotoxic T cell physiology
- abnormal definitive hematopoiesis
- abnormal epidermis stratum corneum morphology
- abnormal erythropoiesis
- abnormal gamma-delta T cell morphology
- abnormal hepatobiliary system morphology
- abnormal humoral immune response
- abnormal immune system organ morphology
- abnormal immune system physiology
- abnormal immunoglobulin level
- abnormal interferon level
- abnormal interleukin level
- abnormal keratinocyte apoptosis
- abnormal keratinocyte physiology
- abnormal lung morphology
- abnormal lymph node morphology
- abnormal macrophage physiology
- abnormal mesenteric lymph node morphology
- abnormal proerythroblast morphology
- abnormal tumor necrosis factor level
- absent Peyer's patches
- absent lymph nodes
- absent thymus medulla
- acanthosis
- alopecia
- amyloidosis
- anemia
- cachexia
- decreased B cell number
- decreased B cell proliferation
- decreased NK T cell number
- decreased Peyer's patch number
- decreased T cell number
- decreased T cell proliferation
- decreased body size
- decreased body weight
- decreased circulating amylase level
- decreased circulating interleukin-4 level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased dendritic cell number
- decreased liver function
- decreased pre-B cell number
- decreased spleen white pulp amount
- decreased susceptibility to type IV hypersensitivity reaction
- dermatitis
- disheveled coat
- distended abdomen
- enlarged spleen
- epidermal hyperplasia
- epididymal inflammation
- extramedullary hematopoiesis
- glomerulonephritis
- hunched posture
- hyperkeratosis
- impaired neutrophil phagocytosis
- increased IgE level
- increased IgM level
- increased bone marrow cell number
- increased eosinophil cell number
- increased granulocyte number
- increased inflammatory response
- increased keratinocyte proliferation
- increased macrophage cell number
- increased respiratory mucosa goblet cell number
- increased spleen red pulp amount
- increased spleen weight
- increased susceptibility to Riboviria infection
- increased susceptibility to bacterial infection
- intestinal inflammation
- lethality at weaning complete penetrance
- liver cirrhosis
- liver failure
- liver fibrosis
- liver inflammation
- lung inflammation
- mixed cellular infiltration to dermis
- myeloid hyperplasia
- myositis
- ovary inflammation
- pale liver
- pathological neovascularization
- premature death
- preweaning lethality incomplete penetrance
- pulmonary alveolar hemorrhage
- pulmonary fibrosis
- reddish skin
- reduced fertility
- ruffled hair
- salivary gland inflammation
- scaly skin
- skin edema
- skin inflammation
- small Peyer's patches
- spleen hyperplasia
- stomach inflammation
- thick dermal layer
- thick epidermis
- thick skin
- thin tail
- thymus atrophy
- thymus hypoplasia
role in cell
- expression in
- transactivation in
- cell death
- differentiation
- activation in
- production in
- binding
- quantity
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intracellular space
- centrosome
- cytosol
- nucleoplasm
- synapse
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Relb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- NIK/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- I-kappaB kinase/NF-kappaB cascade
- T-helper 1 cell differentiation
- circadian regulation of gene expression
- inflammatory response
- cellular response to osmotic stress
- negative regulation of transcription, DNA-dependent
- myeloid dendritic cell differentiation
- innate immune response
- lymphocyte differentiation
- cellular response to stress
- antigen processing and presentation
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- transcriptional repressor complex
- cytosol
- macromolecular complex
- NF-kappaB complex
- synapse
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity