Nfat5 Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; and regulation of calcineurin-NFAT signaling cascade. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human NFAT5 (nuclear factor of activated T cells 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Nfat5 |
| Official Name | nuclear factor of activated T cells 5 [Source:MGI Symbol;Acc:MGI:1859333] |
| Ensembl ID | ENSMUSG00000003847 |
| Bio databases IDs | |
| Aliases | nuclear factor of activated T cells 5 |
| Synonyms | B130038B15RIK, CAG-8, CAG80, mKIAA0827, Nfat, NFATC5, NFATL1, NFATZ, nuclear factor of activated T-cells 5, OREBP, TONEBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfat5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nuclear export signal
- DNA binding domain
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- nuclear localization sequence
- transcription activation domain
- auxiliary export domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- IDD5 domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- N-terminal sub-domain of the Rel homology domain (RHD)
- modulatory domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfat5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- April Mediated Signaling
- Axonal Guidance Signaling
- B Cell Activating Factor Signaling
- B Cell Receptor Signaling
- Calcium Signaling
- CD28 Signaling in T Helper Cells
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- fMLP Signaling in Neutrophils
- G-Protein Coupled Receptor Signaling
- Glucocorticoid Receptor Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- IL-12 Signaling and Production in Macrophages
- Natural Killer Cell Signaling
- Netrin Signaling
- Neuroinflammation Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- breast cancer
- epithelial cancer
- cancer
- interstitial nephritis
- chronic kidney disease
- non-insulin-dependent diabetes mellitus
- edema
- Alzheimer disease
- diabetes mellitus
phenotypes
- preweaning lethality incomplete penetrance
- prolonged QT interval
- prolonged ST segment
- abnormal cardiovascular system physiology
- abnormal fetal cardiomyocyte proliferation
- abnormal fluid regulation
- abnormal immunoglobulin level
- abnormal kidney morphology
- abnormal kidney outer medulla inner stripe morphology
- abnormal kidney outer medulla morphology
- abnormal kidney pelvis morphology
- abnormal myocardial trabeculae morphology
- abnormal myocardium compact layer morphology
- abnormal renal tubule epithelium morphology
- abnormal renal tubule morphology
- anemia
- decreased IgG level
- decreased T cell proliferation
- dilated renal tubules
- edema
- increased kidney apoptosis
- kidney atrophy
- kidney papillary atrophy
- lethality throughout fetal growth and development complete penetrance
- lethality throughout fetal growth and development incomplete penetrance
- perinatal lethality complete penetrance
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- prenatal lethality complete penetrance
- spleen hypoplasia
- thin ventricular wall
- thymus hypoplasia
- tubulointerstitial nephritis
role in cell
- killing
- apoptosis
- activation in
- formation
- production in
- DNA damage response
- expression in
- phosphorylation in
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfat5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- positive regulation of gene expression
- cellular hyperosmotic response
- cellular response to cytokine stimulus
- cytokine production
- regulation of calcineurin-NFAT signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity