Cebpb Gene Summary [Mouse]
Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including liver development; positive regulation of metabolic process; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of gene expression. Located in chromosome; cytoplasm; and nuclear matrix. Part of C/EBP complex. Is expressed in several structures, including adrenal gland; connective tissue; extraembryonic component; genitourinary system; and integumental system. Used to study osteochondrodysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cebpb |
| Official Name | CCAAT/enhancer binding protein (C/EBP), beta [Source:MGI Symbol;Acc:MGI:88373] |
| Ensembl ID | ENSMUSG00000056501 |
| Bio databases IDs | |
| Aliases | CCAAT/enhancer binding protein (C/EBP), beta |
| Synonyms | Agp/eb, ANF-1, ANF-2, CCAAT enhancer binding protein beta, CCAAT/enhancer binding protein beta, CCAAT enhancer-binding protein β, CCAAT/enhancer binding protein β, C/EBP-beta, C/Ebp Beta-Lip, C/EBP-β, Cebp β, C/Ebp β-Lip, CRP2, IL-6DBP, NF-IL6, NF-M, TCF5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cebpb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RD rich domain
- transcription regulator
- regulatory domain
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- chromatin binding
- CR domain
- identical protein binding
- proline rich domain
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- ERK/GSK3 phosphorylation site
- bZIP
- histone acetyltransferase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- ligand-dependent nuclear receptor interactor
- acetylation site
- dimerization domain
- MAPK phosphorylation site
- DNA binding domain
- nucleic acid binding
- GSK3 beta phosphorylation site
- CR1 domain
- nuclear localization sequence
- enzyme binding
- Basic region leucine zipper
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- kinase binding
- basic amino acid motif
- double-stranded DNA binding
- protein homodimerization
- ERK phosphorylation site
- GCN5 binding domain
- protein heterodimerization
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Cebpb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Adipogenesis pathway
- Adrenomedullin signaling pathway
- DNA Methylation and Transcriptional Repression Signaling
- IL-12 Signaling and Production in Macrophages
- IL-17 Signaling
- IL-17A Signaling in Fibroblasts
- IL-6 Signaling
- JAK/Stat Signaling
- Osteoarthritis Pathway
- Prolactin Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Type II Diabetes Mellitus Signaling
- Unfolded protein response
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- esophageal squamous cell carcinoma
- infection
- rheumatoid arthritis
- asthma
- obesity
- Alzheimer disease
- memory deficits
- epithelial cancer
phenotypes
- abnormal T-helper 1 physiology
- abnormal T-helper 2 physiology
- abnormal adipose tissue physiology
- abnormal bone trabecula morphology
- abnormal branching of the mammary ductal tree
- abnormal brown adipose tissue morphology
- abnormal brown adipose tissue physiology
- abnormal cell differentiation
- abnormal cell-mediated immunity
- abnormal circulating free fatty acids level
- abnormal clavicle morphology
- abnormal definitive hematopoiesis
- abnormal enzyme/coenzyme level
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal humoral immune response
- abnormal innate immunity
- abnormal lactation
- abnormal lipid homeostasis
- abnormal lymph node B cell domain morphology
- abnormal lymph node T cell domain morphology
- abnormal lymph node cortex morphology
- abnormal lymph node medulla morphology
- abnormal lymph node medullary cord morphology
- abnormal lymph node secondary follicle morphology
- abnormal macrophage physiology
- abnormal mammary gland development
- abnormal mammary gland duct morphology
- abnormal mammary gland epithelium physiology
- abnormal mucosa-associated lymphoid tissue morphology
- abnormal osteoblast physiology
- abnormal osteoclast differentiation
- abnormal osteoclast morphology
- abnormal osteoclast physiology
- abnormal plasma cell morphology
- abnormal skeletal muscle mass
- abnormal skeleton morphology
- abnormal spleen red pulp morphology
- abnormal spleen secondary B follicle morphology
- abnormal spleen white pulp morphology
- abnormal thoracic cage morphology
- abnormal tumor necrosis factor level
- abnormal zygomatic arch morphology
- absent corpus luteum
- absent estrous cycle
- calcified muscle
- decreased body weight
- decreased bone mineralization
- decreased bone ossification
- decreased bone trabecula number
- decreased bone volume
- decreased brown adipose tissue amount
- decreased cell proliferation
- decreased circulating free fatty acid level
- decreased circulating insulin level
- decreased circulating interleukin-12 level
- decreased circulating leptin level
- decreased circulating triglyceride level
- decreased epididymal fat pad weight
- decreased glycogen catabolism rate
- decreased gonadal fat pad weight
- decreased incidence of induced tumors
- decreased incidence of tumors by chemical induction
- decreased lipoprotein lipase activity
- decreased liver regeneration
- decreased osteoclast cell number
- decreased ovulation rate
- decreased percent body fat/body weight
- decreased sensitivity to induced cell death
- decreased skeletal muscle fiber size
- decreased susceptibility to endotoxin shock
- decreased susceptibility to type IV hypersensitivity reaction
- decreased trabecular bone thickness
- decreased triglyceride level
- decreased uterine fat pad weight
- enhanced osteoblast differentiation
- enlarged axillary lymph nodes
- enlarged inguinal lymph nodes
- enlarged lymph nodes
- enlarged mesenteric lymph nodes
- enlarged spleen
- enlarged submandibular lymph nodes
- expanded mesangial matrix
- extramedullary hematopoiesis
- female infertility
- glomerulonephritis
- granulomatous inflammation
- hemosiderosis
- hypoglycemia
- impaired adaptive thermogenesis
- impaired granulosa cell differentiation
- impaired lipolysis
- impaired luteinization
- impaired macrophage phagocytosis
- impaired ovarian folliculogenesis
- impaired skeletal muscle regeneration
- increased IgG level
- increased bone marrow cell number
- increased bone mineralization
- increased bone ossification
- increased bone resorption
- increased bone trabecula number
- increased bone volume
- increased circulating corticosterone level
- increased circulating glucose level
- increased circulating interleukin-6 level
- increased circulating triglyceride level
- increased insulin sensitivity
- increased interleukin-12 secretion
- increased keratinocyte apoptosis
- increased muscle cell glucose uptake
- increased physiological sensitivity to xenobiotic
- increased susceptibility to bacterial infection
- increased susceptibility to fungal infection
- increased trabecular bone thickness
- mesangial cell hyperplasia
- myositis
- neonatal lethality incomplete penetrance
- no abnormal phenotype detected
- perinatal lethality incomplete penetrance
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality incomplete penetrance
- renal glomerulus hypertrophy
- skeletal muscle fibrosis
- skin lesions
role in cell
- invasion by
- expression in
- proliferation
- growth
- recruitment in
- activation in
- migration
- phosphorylation in
- survival
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nuclear envelope
- nuclear matrix
- centromeres
- chromatin
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cebpb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic cell differentiation
- positive regulation of sodium-dependent phosphate transport
- positive regulation of fat cell differentiation
- transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- mammary gland epithelial cell differentiation
- embryonic placenta development
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- brown fat cell differentiation
- cellular response to amino acid stimulus
- inflammatory response
- immune response
- regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- regulation of osteoclast differentiation
- mammary gland epithelial cell proliferation
- positive regulation of biomineral tissue development
- neuron differentiation
- positive regulation of inflammatory response
- regulation of transcription, DNA-dependent
- acute-phase response
- defense response to bacterium
- regulation of transcription from RNA polymerase II promoter
- ovarian follicle development
- negative regulation of T cell proliferation
- hepatocyte proliferation
- regulation of interleukin-6 production
- response to lipopolysaccharide
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- positive regulation of interleukin-4 production
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- condensed chromosome, centromeric region
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- histone acetyltransferase binding
- protein homodimerization activity
- histone deacetylase binding
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- small conjugating protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- kinase binding