MAP3K14 Gene Summary [Human]
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K14 |
| Official Name | mitogen-activated protein kinase kinase kinase 14 [Source:HGNC Symbol;Acc:HGNC:6853] |
| Ensembl ID | ENSG00000006062 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 14, serine/threonine protein-kinase |
| Synonyms | aly, FTDCR1B, HS, HSNIK, IMD112, mitogen-activated protein kinase kinase kinase 14, NFKB INDUCING KINASE, nf κ b inducing kinase, NIK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- protein serine/threonine kinase
- protein kinase
- catalytic domain
- serine/threonine kinase domain
- TRAF3-binding domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- nucleotide-binding domain
- kinase domain
- leucine-rich repeat
- TRAF binding domain
- Protein Kinases, catalytic domain
- IKK binding domain
Pathways
Biological processes and signaling networks where the MAP3K14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- plasma cell myeloma
- COVID-19
- experimental autoimmune encephalomyelitis
- osteolysis
- NIK deficiency
- eosinophilia
- insulin-dependent diabetes mellitus
- chronic autoimmune hepatitis
- osteoporosis
role in cell
- expression in
- activation
- migration
- cell death
- activation in
- proliferation
- apoptosis
- growth
- production in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- fibrillar center
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to mechanical stimulus
- immune response
- NIK/NF-kappaB cascade
- defense response to virus
- I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity