FAR2 Gene Summary [Human]
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | FAR2 |
| Official Name | fatty acyl-CoA reductase 2 [Source:HGNC Symbol;Acc:HGNC:25531] |
| Ensembl ID | ENSG00000064763 |
| Bio databases IDs | |
| Aliases | fatty acyl-CoA reductase 2, short chain dehydrogenase/reductase family 10E, member 2 |
| Synonyms | A230046P18, AW048109, fatty acyl-CoA reductase 2, HEL-S-81, MLSTD1, RGD1565966, SDR10E2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Male sterility protein
- oxidoreductase
- enzyme
- aldehyde or oxo group:NAD or NADP oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty-acyl-CoA metabolic process
- wax biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity
- fatty-acyl-CoA reductase (alcohol-forming) activity