RAB11FIP3 Gene Summary [Human]
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | RAB11FIP3 |
| Official Name | RAB11 family interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:17224] |
| Ensembl ID | ENSG00000090565 |
| Bio databases IDs | |
| Aliases | RAB11 family interacting protein 3, arfophilin-1 |
| Synonyms | CART1, D030060O14Rik, Eferin, FIP3, FIP3-Rab11, LRRGT00043, mKIAA0665, RAB11 family interacting protein 3, RAB11 family interacting protein 3 (class II), RGD1308952 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB11FIP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- TPR/MLP1/MLP2-like protein
- RNase Y N-terminal region
- PspA/IM30 family
- Rab11 binding domain
- EF-hand domain pair
- protein binding activity, bridging
- enzyme binding
- EFh
- protein binding
- identical protein binding
- Prefoldin subunit
- EF-hand domain
- SynN
- prefoldin
- FIP domain
- protein homodimerization
- Growth-arrest specific micro-tubule binding
- Cell division protein ZapB
- GDP/GTP exchange factor Sec2p
Pathways
Biological processes and signaling networks where the RAB11FIP3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
role in cell
- expression in
- accumulation in
- cell spreading
- assembly
- cytokinesis in
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- tubular endosomal network
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- cilia
- pericentrosomal region
- perinuclear region
- cellular membrane
- Plasma Membrane
- basal bodies
- endosomes
- centrosome
- Mitochondria
- midbody
- cytoplasmic bridges
- cytosol
- Golgi membrane
- trans Golgi network
- endosomal membrane
- nucleoplasm
- perinuclear space
- recycling endosomes
- early endosomes
- cleavage furrow
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB11FIP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- vesicle-mediated transport
- negative regulation of adiponectin secretion
- regulation of cytokinesis
- Golgi to plasma membrane protein transport
- regulation of vesicle-mediated transport
- positive regulation of flagellum assembly
- endocytic recycling
- regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- centriolar satellite
- Golgi membrane
- nucleoplasm
- endocytic vesicle
- centrosome
- intercellular bridge
- endosome
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- recycling endosome
- midbody
- recycling endosome membrane
- endocytic vesicle membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- calcium ion binding
- small GTPase binding
- dynein light intermediate chain binding
- protein binding, bridging
- binding, bridging