GDPD3 Gene Summary [Human]
Enables phosphoric diester hydrolase activity. Involved in N-acylethanolamine metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | GDPD3 |
| Official Name | glycerophosphodiester phosphodiesterase domain containing 3 [Source:HGNC Symbol;Acc:HGNC:28638] |
| Ensembl ID | ENSG00000102886 |
| Bio databases IDs | |
| Aliases | glycerophosphodiester phosphodiesterase domain containing 3 |
| Synonyms | 1110015E22Rik, GDE7, glycerophosphodiester phosphodiesterase domain containing 3, MGC4171, RGD1308386 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GDPD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysophospholipase
- Glycerophosphoryl diester phosphodiesterase family
- enzyme
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the GDPD3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
regulates
- palmitic acid
- triacylglycerol
- oleic acid
- phospholipid
- lysophosphatidylcholine
- lysophosphatidic acid
- N-acylethanolamine
- phosphatidylcholine
role in cell
- incorporation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GDPD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine catabolic process
- glycerophospholipid catabolic process
- N-acylethanolamine metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- metal ion binding
- phosphoric diester hydrolase activity